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PREOPERATIVE CHEMOIMMUNOTHERAPY WITH CARBOPLATIN, EPIDOXORUBICIN, 5-FLUOROURACIL AND ALPHA-2B INTERFERON IN LOCALLY ADVANCED INOPERABLE GASTRIC-CANCER

  • Authors:
    • RV IAFFAIOLI
    • F CAPONIGRO
    • A TORTORIELLO
    • G FACCHINI
    • L BUCCI
    • G SCARAMELLINO
    • G FRASCI
    • V VALLEFUOCO
    • G PERSICO

  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1271
  • Pages: 1271-1275
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Abstract

Twenty-six patients with locally advanced, inoperable gastric cancer were treated with carboplatin, epidoxorubicin, 5-fluorouracil (FEP) plus alpha 2b interferon. Total gastrectomy was performed in patients achieving clinical complete or partial response. The overall response rate after neoadjuvant chemotherapy was 67%. In 13/15 patients undergoing surgery no residual tumor was evident after resection. After a median follow-up of 14 months, 4/13 disease-free patients have relapsed. The median survival time is 13 months for all patients, and 19 months for disease-free patients; in four patients survival time exceeds twenty-four months. Our multimodality program is effective in locally advanced gastric cancer and warrants further evaluation.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Source Normalized Impact per Paper (SNIP): 1.125
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Spandidos Publications style
IAFFAIOLI R, CAPONIGRO F, TORTORIELLO A, FACCHINI G, BUCCI L, SCARAMELLINO G, FRASCI G, VALLEFUOCO V and PERSICO G: PREOPERATIVE CHEMOIMMUNOTHERAPY WITH CARBOPLATIN, EPIDOXORUBICIN, 5-FLUOROURACIL AND ALPHA-2B INTERFERON IN LOCALLY ADVANCED INOPERABLE GASTRIC-CANCER. Int J Oncol 4: 1271-1275, 1994
APA
IAFFAIOLI, R., CAPONIGRO, F., TORTORIELLO, A., FACCHINI, G., BUCCI, L., SCARAMELLINO, G. ... PERSICO, G. (1994). PREOPERATIVE CHEMOIMMUNOTHERAPY WITH CARBOPLATIN, EPIDOXORUBICIN, 5-FLUOROURACIL AND ALPHA-2B INTERFERON IN LOCALLY ADVANCED INOPERABLE GASTRIC-CANCER. International Journal of Oncology, 4, 1271-1275. https://doi.org/10.3892/ijo.4.6.1271
MLA
IAFFAIOLI, R., CAPONIGRO, F., TORTORIELLO, A., FACCHINI, G., BUCCI, L., SCARAMELLINO, G., FRASCI, G., VALLEFUOCO, V., PERSICO, G."PREOPERATIVE CHEMOIMMUNOTHERAPY WITH CARBOPLATIN, EPIDOXORUBICIN, 5-FLUOROURACIL AND ALPHA-2B INTERFERON IN LOCALLY ADVANCED INOPERABLE GASTRIC-CANCER". International Journal of Oncology 4.6 (1994): 1271-1275.
Chicago
IAFFAIOLI, R., CAPONIGRO, F., TORTORIELLO, A., FACCHINI, G., BUCCI, L., SCARAMELLINO, G., FRASCI, G., VALLEFUOCO, V., PERSICO, G."PREOPERATIVE CHEMOIMMUNOTHERAPY WITH CARBOPLATIN, EPIDOXORUBICIN, 5-FLUOROURACIL AND ALPHA-2B INTERFERON IN LOCALLY ADVANCED INOPERABLE GASTRIC-CANCER". International Journal of Oncology 4, no. 6 (1994): 1271-1275. https://doi.org/10.3892/ijo.4.6.1271