NM23 EXPRESSION VERSUS HELIX-POMATIA LECTIN-BINDING IN HUMAN BREAST-CANCER METASTASES

  • Authors:
    • M NOGUCHI
    • M EARASHI
    • I OHNISHI
    • K KINOSHITA
    • M THOMAS
    • S FUSIDA
    • I MIYAZAKI
    • Y MIZUKAMI
  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1353
  • Pages: 1353-1358
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Abstract

The relationship between nm23 expression, HPA staining, and other clinicopathological variables, i.e., axillary (AX) and internal mammary lymph node (IMN) metastases was assessed, and their prognostic values were analyzed. Positive HPA staining was found to be significantly correlated with tumor size, and with AX and IMN metastases, whereas negative nm23 expression was significantly correlated with AX and IMN metastases. A univariate study revealed that overall survival was correlated significantly with tumor size, AX and IMN metastases, and HPA staining, whereas nm23 expression did not appear to be a significant prognostic factor. In a multivariate study, only AX and IMN metastases were significant prognostic factors. When AX and IMN metastases were excluded from the Cox model, however, only HPA staining had independent prognostic value for survival. In this study, therefore, it may be concluded that HPA staining was more closely correlated with AX and IMN metastases, and with survival than nm23 expression.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
NOGUCHI M, EARASHI M, OHNISHI I, KINOSHITA K, THOMAS M, FUSIDA S, MIYAZAKI I and MIZUKAMI Y: NM23 EXPRESSION VERSUS HELIX-POMATIA LECTIN-BINDING IN HUMAN BREAST-CANCER METASTASES. Int J Oncol 4: 1353-1358, 1994
APA
NOGUCHI, M., EARASHI, M., OHNISHI, I., KINOSHITA, K., THOMAS, M., FUSIDA, S. ... MIZUKAMI, Y. (1994). NM23 EXPRESSION VERSUS HELIX-POMATIA LECTIN-BINDING IN HUMAN BREAST-CANCER METASTASES. International Journal of Oncology, 4, 1353-1358. https://doi.org/10.3892/ijo.4.6.1353
MLA
NOGUCHI, M., EARASHI, M., OHNISHI, I., KINOSHITA, K., THOMAS, M., FUSIDA, S., MIYAZAKI, I., MIZUKAMI, Y."NM23 EXPRESSION VERSUS HELIX-POMATIA LECTIN-BINDING IN HUMAN BREAST-CANCER METASTASES". International Journal of Oncology 4.6 (1994): 1353-1358.
Chicago
NOGUCHI, M., EARASHI, M., OHNISHI, I., KINOSHITA, K., THOMAS, M., FUSIDA, S., MIYAZAKI, I., MIZUKAMI, Y."NM23 EXPRESSION VERSUS HELIX-POMATIA LECTIN-BINDING IN HUMAN BREAST-CANCER METASTASES". International Journal of Oncology 4, no. 6 (1994): 1353-1358. https://doi.org/10.3892/ijo.4.6.1353