HER-2/NEU AND FIBRINOLYTIC FACTORS IN HUMAN BREAST-CANCER

  • Authors:
    • S TOMMASI
    • C RELLA
    • C GIANNELLA
    • M QUARANTA
    • F SCHITTULLI
    • A PARADISO
    • M COVIELLO
    • M DELENA
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.473
  • Pages: 473-477
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Abstract

HER-2/neu status and t-PA, u-PA, and PAI-1 cytosol content were evaluated in 88 primary breast cancer patients to determine the relationships between these parameters. HER-2/neu was amplified in 24% (20/84) of tumor samples and overexpressed in 28% (14/50). In the overall series, median t-PA, u-PA and PAI-1 contents, measured by the enzyme-linked immmunoassay (ELISA), resulted in 1.7, 1.1 and 1.0 ng/mg cytosol protein (cyt prot), respectively. HER-2/neu overexpressed cases showed higher u-PA levels than those normally expressed whereas t-PA and PAI-1 levels did not vary in HER-2/neu altered and non altered cases. The t-PA levels did not differ in cases with or without HER-2/neu alterations, when separately considering the node-negative and node-positive cases. A significant relationship between t-PA levels and HER-2/neu alterations was observed only in the ER(+) tumors: t-PA levels were lower in amplified and overexpressed cases (1.4 versus 2.5 ng/mg cyt prot in amplified and single copy gene, respectively; 1.6 versus 2.3 ng/mg cyt prot in overexpressed and normally expressed cases, respectively). Therefore, t-PA and HER-2/neu could provide additional prognostic information for ER-negative patients.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TOMMASI S, RELLA C, GIANNELLA C, QUARANTA M, SCHITTULLI F, PARADISO A, COVIELLO M and DELENA M: HER-2/NEU AND FIBRINOLYTIC FACTORS IN HUMAN BREAST-CANCER. Int J Oncol 5: 473-477, 1994
APA
TOMMASI, S., RELLA, C., GIANNELLA, C., QUARANTA, M., SCHITTULLI, F., PARADISO, A. ... DELENA, M. (1994). HER-2/NEU AND FIBRINOLYTIC FACTORS IN HUMAN BREAST-CANCER. International Journal of Oncology, 5, 473-477. https://doi.org/10.3892/ijo.5.3.473
MLA
TOMMASI, S., RELLA, C., GIANNELLA, C., QUARANTA, M., SCHITTULLI, F., PARADISO, A., COVIELLO, M., DELENA, M."HER-2/NEU AND FIBRINOLYTIC FACTORS IN HUMAN BREAST-CANCER". International Journal of Oncology 5.3 (1994): 473-477.
Chicago
TOMMASI, S., RELLA, C., GIANNELLA, C., QUARANTA, M., SCHITTULLI, F., PARADISO, A., COVIELLO, M., DELENA, M."HER-2/NEU AND FIBRINOLYTIC FACTORS IN HUMAN BREAST-CANCER". International Journal of Oncology 5, no. 3 (1994): 473-477. https://doi.org/10.3892/ijo.5.3.473