ASSOCIATION OF P53 EXPRESSION WITH PROLIFERATIVE ACTIVITY AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL LUNG CARCINOMAS

  • Authors:
    • M VOLM
    • J MATTERN
    • S HECKER
    • EW POMMERENKE
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.533
  • Pages: 533-538
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Abstract

Tumor tissue of 65 patients with squamous cell lung carcinoma was analyzed for p53 expression using immunohistochemistry (DO-1) and for proliferative activity using flow cytometry. Of the 65 cases, 17 cases (26%) showed positive staining for p53, whereas 48 cases (74%) showed no expression. The median survival time for patients with p53-negative tumors was 100 weeks and for patients with p53-positive tumors 30 weeks (rank-sum test, p=0.03; log-rank test, p=0.14). The median survival time for patients with high proliferative activity (proportion of SG(2)M-phase cells >22%) was one year and for patients with low proliferative activity (proportion of SG(2)M-phase cells less than or equal to 22%) over 6 years (rank-sum test, p=0.04; log-rank test, p=0.01). There exists a trend that p53-positive squamous cell lung carcinoma had a higher proportion of SG(2)M-phase cells than p53-negative tumors. Multivariate analysis found independent prognostic significance for proliferative activity and stage but not for p53.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
VOLM M, MATTERN J, HECKER S and POMMERENKE E: ASSOCIATION OF P53 EXPRESSION WITH PROLIFERATIVE ACTIVITY AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL LUNG CARCINOMAS. Int J Oncol 5: 533-538, 1994.
APA
VOLM, M., MATTERN, J., HECKER, S., & POMMERENKE, E. (1994). ASSOCIATION OF P53 EXPRESSION WITH PROLIFERATIVE ACTIVITY AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL LUNG CARCINOMAS. International Journal of Oncology, 5, 533-538. https://doi.org/10.3892/ijo.5.3.533
MLA
VOLM, M., MATTERN, J., HECKER, S., POMMERENKE, E."ASSOCIATION OF P53 EXPRESSION WITH PROLIFERATIVE ACTIVITY AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 5.3 (1994): 533-538.
Chicago
VOLM, M., MATTERN, J., HECKER, S., POMMERENKE, E."ASSOCIATION OF P53 EXPRESSION WITH PROLIFERATIVE ACTIVITY AND POOR-PROGNOSIS IN PATIENTS WITH SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 5, no. 3 (1994): 533-538. https://doi.org/10.3892/ijo.5.3.533