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ENHANCED EXPRESSION OF C-MYC GENE AND BINDING-PROTEIN TO THE 2.3-KB UPSTREAM REGION OF THE P1 PROMOTER IN HUMAN LIVER AND COLON CANCERS

  • Authors:
    • K SAIGO
    • K YAGINUMA
    • H HAYASHI
    • K ISONO
    • S TAKADA
    • K KOIKE

  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/ijo.5.5.1099
  • Pages: 1099-1104
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Abstract

We investigated binding proteins in the upstream regulatory region of c-myc gene in human liver and colon cancers. Gel shift assay revealed a nuclear protein which bound to the HindIII/PstI fragment (nt.-2328 to nt.-2118) upstream of the pi promoter of c-myc gene. DNase I footprinting showed a unique 25bp binding sequence (nt.-2305 to nt.-2281), not related to any reported elements. The amount of binding protein was higher in the cancerous than in the non-cancerous tissues. This suggests that the 25bp sequence possibly functions as a cis-acting positive element of the c-myc gene expression.

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November 1994
Volume 5 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • CiteScore: 11.4
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  • Source Normalized Impact per Paper (SNIP): 1.125
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Spandidos Publications style
SAIGO K, YAGINUMA K, HAYASHI H, ISONO K, TAKADA S and KOIKE K: ENHANCED EXPRESSION OF C-MYC GENE AND BINDING-PROTEIN TO THE 2.3-KB UPSTREAM REGION OF THE P1 PROMOTER IN HUMAN LIVER AND COLON CANCERS. Int J Oncol 5: 1099-1104, 1994
APA
SAIGO, K., YAGINUMA, K., HAYASHI, H., ISONO, K., TAKADA, S., & KOIKE, K. (1994). ENHANCED EXPRESSION OF C-MYC GENE AND BINDING-PROTEIN TO THE 2.3-KB UPSTREAM REGION OF THE P1 PROMOTER IN HUMAN LIVER AND COLON CANCERS. International Journal of Oncology, 5, 1099-1104. https://doi.org/10.3892/ijo.5.5.1099
MLA
SAIGO, K., YAGINUMA, K., HAYASHI, H., ISONO, K., TAKADA, S., KOIKE, K."ENHANCED EXPRESSION OF C-MYC GENE AND BINDING-PROTEIN TO THE 2.3-KB UPSTREAM REGION OF THE P1 PROMOTER IN HUMAN LIVER AND COLON CANCERS". International Journal of Oncology 5.5 (1994): 1099-1104.
Chicago
SAIGO, K., YAGINUMA, K., HAYASHI, H., ISONO, K., TAKADA, S., KOIKE, K."ENHANCED EXPRESSION OF C-MYC GENE AND BINDING-PROTEIN TO THE 2.3-KB UPSTREAM REGION OF THE P1 PROMOTER IN HUMAN LIVER AND COLON CANCERS". International Journal of Oncology 5, no. 5 (1994): 1099-1104. https://doi.org/10.3892/ijo.5.5.1099