CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER

  • Authors:
    • C PETERSSON
    • B JOHANSSON
    • N PANDIS
    • L GORUNOVA
    • C INGVAR
    • I IDVALL
    • N MANDAHL
    • F MITELMAN
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1207
  • Pages: 1207-1210
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Abstract

Short-term cultures of 29 samples of fibrocystic breast disease were cytogenetically analyzed. Clonal chromosome aberrations were found in six specimens, whereas the remaining 23 had a normal karyotype. Three of the abnormal samples displayed karyotypic anomalies previously associated with breast cancer, i.e., gain of Iq, trisomy 18 and cytogenetic multiclonality. Furthermore, all cytogenetically aberrant specimens had either proliferative disease without atypia or atypical hyperplasia, features of fibrocystic disease considered risk factors for subsequent breast cancer development. The cytogenetic similarities between breast carcinomas and proliferative fibrocystic breast disease add further support for classifying certain types of fibrocystic disease as a premalignant condition. Whether cytogenetically abnormal fibrocystic lesions are the ones that subsequently progress to cancer remains to be elucidated.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
PETERSSON C, JOHANSSON B, PANDIS N, GORUNOVA L, INGVAR C, IDVALL I, MANDAHL N and MITELMAN F: CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER. Int J Oncol 5: 1207-1210, 1994
APA
PETERSSON, C., JOHANSSON, B., PANDIS, N., GORUNOVA, L., INGVAR, C., IDVALL, I. ... MITELMAN, F. (1994). CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER. International Journal of Oncology, 5, 1207-1210. https://doi.org/10.3892/ijo.5.6.1207
MLA
PETERSSON, C., JOHANSSON, B., PANDIS, N., GORUNOVA, L., INGVAR, C., IDVALL, I., MANDAHL, N., MITELMAN, F."CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER". International Journal of Oncology 5.6 (1994): 1207-1210.
Chicago
PETERSSON, C., JOHANSSON, B., PANDIS, N., GORUNOVA, L., INGVAR, C., IDVALL, I., MANDAHL, N., MITELMAN, F."CLONAL CHROMOSOME-ABERRATIONS IN FIBROCYSTIC BREAST DISEASE-ASSOCIATED WITH INCREASED RISK OF CANCER". International Journal of Oncology 5, no. 6 (1994): 1207-1210. https://doi.org/10.3892/ijo.5.6.1207