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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 1994 Volume 5 Issue 6

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Article

OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA

  • Authors:
    • H STUMPF
    • P BANNASCH

  • View Affiliations / Copyright

    Affiliations: DEUTSCH KREBSFORSCHUNGSZENTRUM,CYTOPATHOL ABT 0310,D-69120 HEIDELBERG,GERMANY.
  • Pages: 1255-1260
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1255
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Abstract

Abundance of messenger RNA (mRNA) and activity of glucose-6-phosphate dehydrogenase (G6PDH), the rate limiting enzyme of the oxidative pentose phosphate pathway, were studied in preneoplastic foci of altered hepatocytes (FAH) and hepatocellular carcinomas (HCC) induced in rats by limited oral exposure to N-nitrosomorpholine (NNM-stop model). Northern blot analysis revealed increased amounts of G6PDH-mRNA in 9/10 HCC, which are apparently not due to structural alterations of the G6PDH gene as studied by Southern blot analysis. In four additional HCC elevated expression of G6PDH was demonstrated by in situ hybridization to antisense-mRNA and by catalytic enzyme histochemistry. This correlative molecular genetic and enzyme histochemical approach was also used to study G6PDH expression in FAH of different phenotypes, namely glycogen storage foci (GSF), mixed cell foci (MCF) acid basophilic cell foci (BCF), representing early (GSF) and advanced (MCF, BCF) stages of hepatic preneoplasia. mRNA level and activity of G6PDH were closely correlated in all types of lesions and increased from GSF to MCF/BCF and HCC. These results suggest a predominantly transcriptional regulation of the increasing expression of G6PDH during hepatocarcinogenesis in the rat.

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Copy and paste a formatted citation
Spandidos Publications style
STUMPF H and BANNASCH P: OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA. Int J Oncol 5: 1255-1260, 1994.
APA
STUMPF, H., & BANNASCH, P. (1994). OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA. International Journal of Oncology, 5, 1255-1260. https://doi.org/10.3892/ijo.5.6.1255
MLA
STUMPF, H., BANNASCH, P."OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA". International Journal of Oncology 5.6 (1994): 1255-1260.
Chicago
STUMPF, H., BANNASCH, P."OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA". International Journal of Oncology 5, no. 6 (1994): 1255-1260. https://doi.org/10.3892/ijo.5.6.1255
Copy and paste a formatted citation
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Spandidos Publications style
STUMPF H and BANNASCH P: OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA. Int J Oncol 5: 1255-1260, 1994.
APA
STUMPF, H., & BANNASCH, P. (1994). OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA. International Journal of Oncology, 5, 1255-1260. https://doi.org/10.3892/ijo.5.6.1255
MLA
STUMPF, H., BANNASCH, P."OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA". International Journal of Oncology 5.6 (1994): 1255-1260.
Chicago
STUMPF, H., BANNASCH, P."OVEREXPRESSION OF GLUCOSE-6-PHOSPHATE-DEHYDROGENASE IN RAT HEPATIC PRENEOPLASIA AND NEOPLASIA". International Journal of Oncology 5, no. 6 (1994): 1255-1260. https://doi.org/10.3892/ijo.5.6.1255
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