TRANSFORMATION OF MURINE FIBROBLASTS BY UV-LIGHT AND TGF-BETA - ESTABLISHMENT OF AN AUTOCRINE TGF-BETA LOOP

  • Authors:
    • I WEHRLE
    • A JAKOB
    • P HOFLER
    • G BAUER
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1341
  • Pages: 1341-1346
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Abstract

Murine fibroblasts stably transformed by initiation with UV light and tumor promotion with TGF-beta form colonies in soft agar, exhibit a diffuse actin pattern and induce angiogenesis. They differ from their parental cells by their ability to release active TGF and to react to TGF-beta by increased colony formation. Antibodies directed against TGF-beta abrogate the transformed phenotype, indicating the action of an autocrine TGF-beta loop for the maintenance of the transformed state. However, TGF-beta which is responsible for the maintenance of the transformed state, proves to be a severe obstacle for the survival of transformed cells which are cocultivated with normal cells.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
WEHRLE I, JAKOB A, HOFLER P and BAUER G: TRANSFORMATION OF MURINE FIBROBLASTS BY UV-LIGHT AND TGF-BETA - ESTABLISHMENT OF AN AUTOCRINE TGF-BETA LOOP. Int J Oncol 5: 1341-1346, 1994
APA
WEHRLE, I., JAKOB, A., HOFLER, P., & BAUER, G. (1994). TRANSFORMATION OF MURINE FIBROBLASTS BY UV-LIGHT AND TGF-BETA - ESTABLISHMENT OF AN AUTOCRINE TGF-BETA LOOP. International Journal of Oncology, 5, 1341-1346. https://doi.org/10.3892/ijo.5.6.1341
MLA
WEHRLE, I., JAKOB, A., HOFLER, P., BAUER, G."TRANSFORMATION OF MURINE FIBROBLASTS BY UV-LIGHT AND TGF-BETA - ESTABLISHMENT OF AN AUTOCRINE TGF-BETA LOOP". International Journal of Oncology 5.6 (1994): 1341-1346.
Chicago
WEHRLE, I., JAKOB, A., HOFLER, P., BAUER, G."TRANSFORMATION OF MURINE FIBROBLASTS BY UV-LIGHT AND TGF-BETA - ESTABLISHMENT OF AN AUTOCRINE TGF-BETA LOOP". International Journal of Oncology 5, no. 6 (1994): 1341-1346. https://doi.org/10.3892/ijo.5.6.1341