EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE

  • Authors:
    • S BARDOCZ
    • G GRANT
    • A PUSZTAI
    • TJ DUGUID
    • DS BROWN
    • IF PRYME
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1369
  • Pages: 1369-1374
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Abstract

Neoplastic proliferation requires the availability of polyamines. Phytohaemagglutinin (PHA) is a potent growth factor which induces polyamine-dependent growth of the gut. In the hope of directing polyamines and other nutrients away from the tumour to the growing gut, mice fed PHA-containing or lactalbumin diets were injected intraperitoneally with Krebs II ascites cells and the number of tumour cells and the weights of internal organs were followed. PHA-treatment significantly slowed down the proliferation of tumour cells. Changes in the weight and polyamine content of tissues indicated that inter-organ competition between the tumour and vital organs can be used to manipulate the metabolism of tumour-bearing mice.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BARDOCZ S, GRANT G, PUSZTAI A, DUGUID T, BROWN D and PRYME I: EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE. Int J Oncol 5: 1369-1374, 1994
APA
BARDOCZ, S., GRANT, G., PUSZTAI, A., DUGUID, T., BROWN, D., & PRYME, I. (1994). EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE. International Journal of Oncology, 5, 1369-1374. https://doi.org/10.3892/ijo.5.6.1369
MLA
BARDOCZ, S., GRANT, G., PUSZTAI, A., DUGUID, T., BROWN, D., PRYME, I."EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE". International Journal of Oncology 5.6 (1994): 1369-1374.
Chicago
BARDOCZ, S., GRANT, G., PUSZTAI, A., DUGUID, T., BROWN, D., PRYME, I."EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE". International Journal of Oncology 5, no. 6 (1994): 1369-1374. https://doi.org/10.3892/ijo.5.6.1369