EFFECT OF PHYTOHEMAGGLUTININ ON THE GROWTH OF KREBS-II TUMOR-CELLS, BODY METABOLISM AND INTERNAL ORGANS OF MICE
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- Published online on: December 1, 1994 https://doi.org/10.3892/ijo.5.6.1369
- Pages: 1369-1374
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Abstract
Neoplastic proliferation requires the availability of polyamines. Phytohaemagglutinin (PHA) is a potent growth factor which induces polyamine-dependent growth of the gut. In the hope of directing polyamines and other nutrients away from the tumour to the growing gut, mice fed PHA-containing or lactalbumin diets were injected intraperitoneally with Krebs II ascites cells and the number of tumour cells and the weights of internal organs were followed. PHA-treatment significantly slowed down the proliferation of tumour cells. Changes in the weight and polyamine content of tissues indicated that inter-organ competition between the tumour and vital organs can be used to manipulate the metabolism of tumour-bearing mice.