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LOSS OF HETEROZYGOSITY ON CHROMOSOME 16Q, EXPRESSION OF HER2/NEU AND P53 MUTATIONS IN ENDOMETRIAL CANCER

  • Authors:
    • G MASSENKEIL
    • R CADUFF
    • H OBERHUBER
    • I SCHWARTE-WALDHOFF
    • PA DIENER
    • F BANNWART
    • H WALT
    • R SCHAFER

  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.157
  • Pages: 157-162
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Abstract

We analyzed endometrial adenocarcinomas for mutations of the p53 anti-oncogene, expression of the HER2/neu oncogene and for loss of heterozygosity on chromosome 16q. p53 mutations were found in 3 of 25 tumors. Elevated expression of HER2/neu found in 7 of 24 tumors involves a mechanism other than gene amplification. LOH on chromosome 16q22-24 was observed in 4 of 13 informative tumors. Four of 25 endometrial tumors exhibited two or more alterations. Tumors with the highest HER2/neu protein level exhibited a negative progesterone receptor status. Accumulation of these changes may determine the biological behaviour of a subset of endometrial tumors.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MASSENKEIL G, CADUFF R, OBERHUBER H, SCHWARTE-WALDHOFF I, DIENER P, BANNWART F, WALT H and SCHAFER R: LOSS OF HETEROZYGOSITY ON CHROMOSOME 16Q, EXPRESSION OF HER2/NEU AND P53 MUTATIONS IN ENDOMETRIAL CANCER. Int J Oncol 6: 157-162, 1995
APA
MASSENKEIL, G., CADUFF, R., OBERHUBER, H., SCHWARTE-WALDHOFF, I., DIENER, P., BANNWART, F. ... SCHAFER, R. (1995). LOSS OF HETEROZYGOSITY ON CHROMOSOME 16Q, EXPRESSION OF HER2/NEU AND P53 MUTATIONS IN ENDOMETRIAL CANCER. International Journal of Oncology, 6, 157-162. https://doi.org/10.3892/ijo.6.1.157
MLA
MASSENKEIL, G., CADUFF, R., OBERHUBER, H., SCHWARTE-WALDHOFF, I., DIENER, P., BANNWART, F., WALT, H., SCHAFER, R."LOSS OF HETEROZYGOSITY ON CHROMOSOME 16Q, EXPRESSION OF HER2/NEU AND P53 MUTATIONS IN ENDOMETRIAL CANCER". International Journal of Oncology 6.1 (1995): 157-162.
Chicago
MASSENKEIL, G., CADUFF, R., OBERHUBER, H., SCHWARTE-WALDHOFF, I., DIENER, P., BANNWART, F., WALT, H., SCHAFER, R."LOSS OF HETEROZYGOSITY ON CHROMOSOME 16Q, EXPRESSION OF HER2/NEU AND P53 MUTATIONS IN ENDOMETRIAL CANCER". International Journal of Oncology 6, no. 1 (1995): 157-162. https://doi.org/10.3892/ijo.6.1.157