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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 6 Issue 1

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Article

IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130

  • Authors:
    • TH HU
    • SC FERRIL
    • AM SNIDER
    • MS BARBOSA

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,SW MED CTR,DEPT MICROBIOL,DALLAS,TX 75235.
  • Pages: 167-174
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.167
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Abstract

The two-hybrid system was used to detect interactions in vivo between HPV E7 and three 'Rb-like proteins', pRb, p107 and p130. The association between pE7 and pRb parallel the oncogenic potential of the specific HPV types. In contrast, the interaction between pE7 and p107 or p130 differ. While the HPV 16 E7 protein associates with the 'Rb-like' proteins strongly, both HPV 18 and 6b E7 proteins bind more weakly. We tested several HPV 6 E7 mutants carrying single amino acid mutations. Substitution of the glycine at position 22 with an aspartate was the only mutation capable of increasing the ability of HPV 6 E7 protein to bind pRb. However, association with p107 and p130 by the HPV 6 E7 protein was also increased by mutation of the arginine at position 4 with an aspartate. These data suggest that pRb, p107 and p130 interact with similar but non-identical domains of pE7. In addition, we used amphotropic retroviruses encoding the HPV 18 E6 and the different E7 genes to analyze their immortalizing activity. The wild-type HPV Is and 16 E7 genes complemented the HPV 18 E6 gene to immortalize human keratinocytes. In comparison, none of the cells infected with HPV 6 E7, wildtype or mutant- encoding retroviruses, became immortal. Thus, our data suggest that HPV 6 E7 lacks a property independent of pRb-association which is required for immortalization of human keratinocytes.

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Copy and paste a formatted citation
Spandidos Publications style
HU T, FERRIL S, SNIDER A and BARBOSA M: IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130. Int J Oncol 6: 167-174, 1995.
APA
HU, T., FERRIL, S., SNIDER, A., & BARBOSA, M. (1995). IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130. International Journal of Oncology, 6, 167-174. https://doi.org/10.3892/ijo.6.1.167
MLA
HU, T., FERRIL, S., SNIDER, A., BARBOSA, M."IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130". International Journal of Oncology 6.1 (1995): 167-174.
Chicago
HU, T., FERRIL, S., SNIDER, A., BARBOSA, M."IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130". International Journal of Oncology 6, no. 1 (1995): 167-174. https://doi.org/10.3892/ijo.6.1.167
Copy and paste a formatted citation
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Spandidos Publications style
HU T, FERRIL S, SNIDER A and BARBOSA M: IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130. Int J Oncol 6: 167-174, 1995.
APA
HU, T., FERRIL, S., SNIDER, A., & BARBOSA, M. (1995). IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130. International Journal of Oncology, 6, 167-174. https://doi.org/10.3892/ijo.6.1.167
MLA
HU, T., FERRIL, S., SNIDER, A., BARBOSA, M."IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130". International Journal of Oncology 6.1 (1995): 167-174.
Chicago
HU, T., FERRIL, S., SNIDER, A., BARBOSA, M."IN-VIVO ANALYSIS OF HPV E7 PROTEIN ASSOCIATION WITH PRB, P107 AND P130". International Journal of Oncology 6, no. 1 (1995): 167-174. https://doi.org/10.3892/ijo.6.1.167
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