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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1995 Volume 6 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1995 Volume 6 Issue 2

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Article

PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG

  • Authors:
    • M VOLM
    • R KOOMAGI
    • J MATTERN

  • View Affiliations / Copyright

    Affiliations: TARTU STATE UNIV,DEPT RADIOL & ONCOL,TARTU,ESTONIA.
  • Pages: 359-362
    |
    Published online on: February 1, 1995
       https://doi.org/10.3892/ijo.6.2.359
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Abstract

The aim of the study was to investigate the prognostic value of the proliferating cell nuclear antigen (PCNA) expression in non-small cell lung carcinomas (NSCLC). Two hundred and sixteen patients with previously untreated NSCLC entered into this investigation. For assessment of PCNA expression the streptavidin-biotinylated peroxidase complex method was performed using imnuunohistochemistry and Mab PC10. The tumors were scored for the percentage of PCNA-positive cells (low proliferative activity less than or equal to 25%; high proliferative activity >25%). Univariate analyses of all patients showed a trend that those with high proliferating tumors had shorter survival times than those with lower proliferating tumors. Similar results were obtained when the analysis was restricted to squamous cell carcinomas. Patients with adenocarcinomas and with high proliferating tumors had significantly shorter survival times than those with low proliferating tumors (p=0.028). No correlation was found between extent of tumors or metastasis and expression of PCNA. The multivariate analysis including age, sex, extent of tumors and metastasis as well as PCNA revealed a highly significant influence of extent of tumors (p=0.007) and metastasis (p=0.003) whereas all other factors including PCNA were of no significant influence.

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Copy and paste a formatted citation
Spandidos Publications style
VOLM M, KOOMAGI R and MATTERN J: PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG. Int J Oncol 6: 359-362, 1995.
APA
VOLM, M., KOOMAGI, R., & MATTERN, J. (1995). PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG. International Journal of Oncology, 6, 359-362. https://doi.org/10.3892/ijo.6.2.359
MLA
VOLM, M., KOOMAGI, R., MATTERN, J."PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG". International Journal of Oncology 6.2 (1995): 359-362.
Chicago
VOLM, M., KOOMAGI, R., MATTERN, J."PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG". International Journal of Oncology 6, no. 2 (1995): 359-362. https://doi.org/10.3892/ijo.6.2.359
Copy and paste a formatted citation
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Spandidos Publications style
VOLM M, KOOMAGI R and MATTERN J: PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG. Int J Oncol 6: 359-362, 1995.
APA
VOLM, M., KOOMAGI, R., & MATTERN, J. (1995). PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG. International Journal of Oncology, 6, 359-362. https://doi.org/10.3892/ijo.6.2.359
MLA
VOLM, M., KOOMAGI, R., MATTERN, J."PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG". International Journal of Oncology 6.2 (1995): 359-362.
Chicago
VOLM, M., KOOMAGI, R., MATTERN, J."PROGNOSTIC-SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN ADENOCARCINOMA OF THE LUNG". International Journal of Oncology 6, no. 2 (1995): 359-362. https://doi.org/10.3892/ijo.6.2.359
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