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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1995 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1995 Volume 6 Issue 3

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Article

CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE

  • Authors:
    • Y SHIRAISHI

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    Affiliations: Affliations not specified
  • Pages: 569-578
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    Published online on: March 1, 1995
       https://doi.org/10.3892/ijo.6.3.569
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Abstract

The phenomenon of sister chromatid exchange (SCE) is an interesting genetic event in metaphase chromosomes, even though its exact mechanism remains unknown. The fact that SCE can take place, whether 'spontaneously' or induced by various agents, is in itself important, for such an event, involving damage and possible repair of bilateral loci in chromosomes, presents opportunities for modification of the cell characters (e.g. oncogene activation). BS B- lymphoblastoid cell lines with high SCE levels were highly susceptible to malignant transformation by chemical carcinogenesis, in which cancer antigens are expressed on the cell surface with the disappearance of immunoglobulin (Ig), when the number of SCE exceeded 140 SCE per cell (over the baseline of 70 SCE per cell). The existence of an increased level of SCE which might cause unequal recombination between either sister chromatids or chromatids of homologous chromosomes may reflect phenomena secondary to malignant transformation or may have played a key role in initiation and maintenance of expression of the oncogenes and the antigens associated with cancers.

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Copy and paste a formatted citation
Spandidos Publications style
SHIRAISHI Y: CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE. Int J Oncol 6: 569-578, 1995.
APA
SHIRAISHI, Y. (1995). CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE. International Journal of Oncology, 6, 569-578. https://doi.org/10.3892/ijo.6.3.569
MLA
SHIRAISHI, Y."CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE". International Journal of Oncology 6.3 (1995): 569-578.
Chicago
SHIRAISHI, Y."CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE". International Journal of Oncology 6, no. 3 (1995): 569-578. https://doi.org/10.3892/ijo.6.3.569
Copy and paste a formatted citation
x
Spandidos Publications style
SHIRAISHI Y: CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE. Int J Oncol 6: 569-578, 1995.
APA
SHIRAISHI, Y. (1995). CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE. International Journal of Oncology, 6, 569-578. https://doi.org/10.3892/ijo.6.3.569
MLA
SHIRAISHI, Y."CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE". International Journal of Oncology 6.3 (1995): 569-578.
Chicago
SHIRAISHI, Y."CANCER ANTIGEN EXPRESSION AND CHROMOSOMAL CHANGES IN A CARCINOGEN-TRANSFORMED BLOOM-SYNDROME B-LYMPHOBLASTOID CELL-LINE". International Journal of Oncology 6, no. 3 (1995): 569-578. https://doi.org/10.3892/ijo.6.3.569
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