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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1995 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1995 Volume 6 Issue 3

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Article

MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION

  • Authors:
    • MJ BELLO
    • PE LEONE
    • P NEBREDA
    • ME KUSAK
    • JM DECAMPOS
    • J VAQUERO
    • JL SARASA
    • A PESTANA
    • JA REY

  • View Affiliations / Copyright

    Affiliations: CSIC,INST INVEST BIOMED,E-28029 MADRID,SPAIN. HOSP PRINCESA,DEPT NEUROSURG,MADRID,SPAIN. FDN JIMENEZ DIAZ,DEPT NEUROSURG,E-28040 MADRID,SPAIN. CLIN PUERTA HIERRO,DEPT NEUROSURG,MADRID,SPAIN. FDN JIMENEZ DIAZ,DEPT ANAT PATHOL,E-28040 MADRID,SPAIN.
  • Pages: 655-658
    |
    Published online on: March 1, 1995
       https://doi.org/10.3892/ijo.6.3.655
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Abstract

A deletion mapping analysis of chromosome 19 was performed on a series of 101 samples derived from malignant gliomas. A total of 35 tumors displayed different deletions for the loci studied (D19S21, D19S11, D19S74, D19S7, D19S8, CKM, and D19S22). In most instances, losses involving the long arm markers of chromosome 19 were observed, and only four samples were characterized by losses on the short arm. No tumor was found displaying loss of both short and long arm markers. The higher frequency of deletions was detected in tumors with a major oligodendroglial component: 76% of samples included in this group displayed losses at 19q. Among the astrocytic tumors, the frequency of 19q alterations varied as follows: 11% in pilocytic astrocytomas, 17% in astrocytomas grade II, 10% in anaplastic astrocytomas and 21% in glioblastoma multiforme. No ependymoma was found displaying allele loss on chromosome 19. The common region of overlap for the 19q deletions observed involves primarily the distal portion of the long arm, 19q13.2-q13.4. In agreement with previous reports, these data suggest the non-random involvement of a tumor suppressor gene located at 19q13 in the genesis or progression of malignant gliomas.

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Copy and paste a formatted citation
Spandidos Publications style
BELLO M, LEONE P, NEBREDA P, KUSAK M, DECAMPOS J, VAQUERO J, SARASA J, PESTANA A and REY J: MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. Int J Oncol 6: 655-658, 1995.
APA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J. ... REY, J. (1995). MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. International Journal of Oncology, 6, 655-658. https://doi.org/10.3892/ijo.6.3.655
MLA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6.3 (1995): 655-658.
Chicago
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6, no. 3 (1995): 655-658. https://doi.org/10.3892/ijo.6.3.655
Copy and paste a formatted citation
x
Spandidos Publications style
BELLO M, LEONE P, NEBREDA P, KUSAK M, DECAMPOS J, VAQUERO J, SARASA J, PESTANA A and REY J: MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. Int J Oncol 6: 655-658, 1995.
APA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J. ... REY, J. (1995). MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. International Journal of Oncology, 6, 655-658. https://doi.org/10.3892/ijo.6.3.655
MLA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6.3 (1995): 655-658.
Chicago
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6, no. 3 (1995): 655-658. https://doi.org/10.3892/ijo.6.3.655
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