MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION

  • Authors:
    • MJ BELLO
    • PE LEONE
    • P NEBREDA
    • ME KUSAK
    • JM DECAMPOS
    • J VAQUERO
    • JL SARASA
    • A PESTANA
    • JA REY
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.655
  • Pages: 655-658
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Abstract

A deletion mapping analysis of chromosome 19 was performed on a series of 101 samples derived from malignant gliomas. A total of 35 tumors displayed different deletions for the loci studied (D19S21, D19S11, D19S74, D19S7, D19S8, CKM, and D19S22). In most instances, losses involving the long arm markers of chromosome 19 were observed, and only four samples were characterized by losses on the short arm. No tumor was found displaying loss of both short and long arm markers. The higher frequency of deletions was detected in tumors with a major oligodendroglial component: 76% of samples included in this group displayed losses at 19q. Among the astrocytic tumors, the frequency of 19q alterations varied as follows: 11% in pilocytic astrocytomas, 17% in astrocytomas grade II, 10% in anaplastic astrocytomas and 21% in glioblastoma multiforme. No ependymoma was found displaying allele loss on chromosome 19. The common region of overlap for the 19q deletions observed involves primarily the distal portion of the long arm, 19q13.2-q13.4. In agreement with previous reports, these data suggest the non-random involvement of a tumor suppressor gene located at 19q13 in the genesis or progression of malignant gliomas.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BELLO M, LEONE P, NEBREDA P, KUSAK M, DECAMPOS J, VAQUERO J, SARASA J, PESTANA A and REY J: MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. Int J Oncol 6: 655-658, 1995
APA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J. ... REY, J. (1995). MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION. International Journal of Oncology, 6, 655-658. https://doi.org/10.3892/ijo.6.3.655
MLA
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6.3 (1995): 655-658.
Chicago
BELLO, M., LEONE, P., NEBREDA, P., KUSAK, M., DECAMPOS, J., VAQUERO, J., SARASA, J., PESTANA, A., REY, J."MOLECULAR ABNORMALITIES OF CHROMOSOME-19 IN MALIGNANT GLIOMAS - PREFERENTIAL INVOLVEMENT OF THE 19Q13.2-Q13.4 REGION". International Journal of Oncology 6, no. 3 (1995): 655-658. https://doi.org/10.3892/ijo.6.3.655