THE EFFECT OF ZYMOSAN-INDUCED GENERALIZED INFLAMMATION ON TUMOR-GROWTH IN A RAT RENAL-CELL CARCINOMA MODEL

  • Authors:
    • APM BOLL
    • T WOBBES
    • GAP NIEUWENHUIJZEN
    • JA SCHALKEN
    • RJA GORIS
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.713
  • Pages: 713-717
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Abstract

We investigated the inhibition of tumour growth by induction of a generalized inflammatory response. 45 Lewis rats were randomly divided in three groups. A rat renal cell carcinoma was transplanted subcutaneously on day one in group I and group II. When the tumour became measurable on day 16, a generalized inflammation was induced by intraperitoneal injection with a suspension of zymosan and paraffin in group I and in group III, consisting of non-tumour bearing animals. Group II was inoculated with paraffin only. Seven and 14 days following intraperitoneal injection two rats out both group I and group II were sacrificed in order to obtain tumour biopsies at different stages of a generalized inflammatory response. Spontaneous mortality occurred twice in group III, consisting of non-tumour bearing animals. On day 37 all surviving rats were killed. Microscopical examination was carried out on all tumours and on lungs, liver, spleen and kidneys. A generalized inflammation response was confirmed in group I and III through biologic and microscopic parameters. After a zymosan induced generalized inflammation response in the rat, tumour growth rate was significantly lower compared with paraffin treated animals.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BOLL A, WOBBES T, NIEUWENHUIJZEN G, SCHALKEN J and GORIS R: THE EFFECT OF ZYMOSAN-INDUCED GENERALIZED INFLAMMATION ON TUMOR-GROWTH IN A RAT RENAL-CELL CARCINOMA MODEL. Int J Oncol 6: 713-717, 1995.
APA
BOLL, A., WOBBES, T., NIEUWENHUIJZEN, G., SCHALKEN, J., & GORIS, R. (1995). THE EFFECT OF ZYMOSAN-INDUCED GENERALIZED INFLAMMATION ON TUMOR-GROWTH IN A RAT RENAL-CELL CARCINOMA MODEL. International Journal of Oncology, 6, 713-717. https://doi.org/10.3892/ijo.6.3.713
MLA
BOLL, A., WOBBES, T., NIEUWENHUIJZEN, G., SCHALKEN, J., GORIS, R."THE EFFECT OF ZYMOSAN-INDUCED GENERALIZED INFLAMMATION ON TUMOR-GROWTH IN A RAT RENAL-CELL CARCINOMA MODEL". International Journal of Oncology 6.3 (1995): 713-717.
Chicago
BOLL, A., WOBBES, T., NIEUWENHUIJZEN, G., SCHALKEN, J., GORIS, R."THE EFFECT OF ZYMOSAN-INDUCED GENERALIZED INFLAMMATION ON TUMOR-GROWTH IN A RAT RENAL-CELL CARCINOMA MODEL". International Journal of Oncology 6, no. 3 (1995): 713-717. https://doi.org/10.3892/ijo.6.3.713