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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1995 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1995 Volume 6 Issue 4

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Article

LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL

  • Authors:
    • CG FISCHER
    • W SCHENDEL
    • C BLUETHNERHAESSLER
    • RH RINGERT

  • View Affiliations / Copyright

    Affiliations: UNIV GOTTINGEN,DEPT UROL,D-37075 GOTTINGEN,GERMANY.
  • Pages: 783-790
    |
    Published online on: April 1, 1995
       https://doi.org/10.3892/ijo.6.4.783
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Abstract

The effect of chemotherapeutic and/or immunotherapeutic drugs on cells obtained from primarily cultured renal cell carcinoma (RCC) was investigated in a microcalorimetric study. This method enables the detection of heat flow in the submicrowatt range, which corresponds to a 1.0x10(-6) degrees C temperature change. The thermal power of 10 individual cell lines from patients with advanced RCC was measured by incubating cells with or without anti-cancer drugs (5-fluorouracil, interferon-alpha-2a, interleukin-2). Using a 4-channel microcalorimeter, it could be shown, that the combination of 5-FU with IFN-alpha-2a or IFN-alpha-2a plus IL-2 led to a significant reduction in thermal cell activity, compared with the addition of 5-FU on its own. These microcalorimetric observations appear to reflect the anti-neoplastic properties of the drugs tested in this study when compared with the findings in a calorimetric assay (MTT-assay).

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Copy and paste a formatted citation
Spandidos Publications style
FISCHER C, SCHENDEL W, BLUETHNERHAESSLER C and RINGERT R: LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. Int J Oncol 6: 783-790, 1995.
APA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., & RINGERT, R. (1995). LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. International Journal of Oncology, 6, 783-790. https://doi.org/10.3892/ijo.6.4.783
MLA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6.4 (1995): 783-790.
Chicago
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6, no. 4 (1995): 783-790. https://doi.org/10.3892/ijo.6.4.783
Copy and paste a formatted citation
x
Spandidos Publications style
FISCHER C, SCHENDEL W, BLUETHNERHAESSLER C and RINGERT R: LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. Int J Oncol 6: 783-790, 1995.
APA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., & RINGERT, R. (1995). LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. International Journal of Oncology, 6, 783-790. https://doi.org/10.3892/ijo.6.4.783
MLA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6.4 (1995): 783-790.
Chicago
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6, no. 4 (1995): 783-790. https://doi.org/10.3892/ijo.6.4.783
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