LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL

  • Authors:
    • CG FISCHER
    • W SCHENDEL
    • C BLUETHNERHAESSLER
    • RH RINGERT
  • View Affiliations

  • Published online on: April 1, 1995     https://doi.org/10.3892/ijo.6.4.783
  • Pages: 783-790
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Abstract

The effect of chemotherapeutic and/or immunotherapeutic drugs on cells obtained from primarily cultured renal cell carcinoma (RCC) was investigated in a microcalorimetric study. This method enables the detection of heat flow in the submicrowatt range, which corresponds to a 1.0x10(-6) degrees C temperature change. The thermal power of 10 individual cell lines from patients with advanced RCC was measured by incubating cells with or without anti-cancer drugs (5-fluorouracil, interferon-alpha-2a, interleukin-2). Using a 4-channel microcalorimeter, it could be shown, that the combination of 5-FU with IFN-alpha-2a or IFN-alpha-2a plus IL-2 led to a significant reduction in thermal cell activity, compared with the addition of 5-FU on its own. These microcalorimetric observations appear to reflect the anti-neoplastic properties of the drugs tested in this study when compared with the findings in a calorimetric assay (MTT-assay).

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April 1995
Volume 6 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
FISCHER C, SCHENDEL W, BLUETHNERHAESSLER C and RINGERT R: LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. Int J Oncol 6: 783-790, 1995
APA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., & RINGERT, R. (1995). LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL. International Journal of Oncology, 6, 783-790. https://doi.org/10.3892/ijo.6.4.783
MLA
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6.4 (1995): 783-790.
Chicago
FISCHER, C., SCHENDEL, W., BLUETHNERHAESSLER, C., RINGERT, R."LONG-TERM MICROCALORIMETRIC FINDINGS IN RENAL-CELL CARCINOMA EXPOSED TO INTERFERON-ALPHA-2A, INTERLEUKIN-2 AND 5-FLUOROURACIL". International Journal of Oncology 6, no. 4 (1995): 783-790. https://doi.org/10.3892/ijo.6.4.783