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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1995 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1995 Volume 6 Issue 4

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Article

COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS

  • Authors:
    • I SALMON
    • P CRAS
    • M REMMELINK
    • S HENRION
    • JL PASTEELS
    • J BROTCHI
    • R KISS

  • View Affiliations / Copyright

    Affiliations: FREE UNIV BRUSSELS,FAC MED,HISTOL LAB,B-1070 BRUSSELS,BELGIUM. FREE UNIV BRUSSELS,HOP ERASME,SERV ANAT PATHOL,B-1070 BRUSSELS,BELGIUM. UNIV INSTELLING ANTWERP,B-2610 WILRIJK,BELGIUM. FREE UNIV BRUSSELS,HOP ERASME,SERV NEUROCHIRURG,B-1070 BRUSSELS,BELGIUM.
  • Pages: 919-924
    |
    Published online on: April 1, 1995
       https://doi.org/10.3892/ijo.6.4.919
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Abstract

Computer-assisted microscope analyses of Feulgen-stained nuclei were used to quantitatively describe the chromatin pattern and to determine the DNA ploidy level in a series of 70 cases including 46 low-grade (benign) ependymomas, 17 anaplastic (malignant) ependymomas, 3 choroid plexus papillomas (benign) and 4 choroid plexus carcinomas (malignant). While the quantitative description of the chromatin pattern was carried out by means of 14 morphonuclear parameters relating to geometric, densitometric and textural features, the DNA ploidy level was assessed by means of DNA histogram typing. Of these 70 cases, proliferative activity was assessed on 24, for which tissue was still available after the digital cell image analyses. This assessment was carried out by means of the determination of the immunohistochemical MIB-1 staining relating to the Ki-67 antigen. The results show that the determination of morphonuclear characteristics did not make it possible to distinguish between ependymal and choroid plexus tumours. Furthermore, neither the computer-assisted microscope analyses of morphonuclear characteritics nor the DNA ploidy level determination made it possible to distinguish between low-grade and anaplastic ependymomas. In sharp contrast, the determination of proliferative activity by means of the Ki-67 antigen immunohistochemical staining enabled such a distinction to be made.

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Copy and paste a formatted citation
Spandidos Publications style
SALMON I, CRAS P, REMMELINK M, HENRION S, PASTEELS J, BROTCHI J and KISS R: COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS. Int J Oncol 6: 919-924, 1995.
APA
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., & KISS, R. (1995). COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS. International Journal of Oncology, 6, 919-924. https://doi.org/10.3892/ijo.6.4.919
MLA
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., KISS, R."COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS". International Journal of Oncology 6.4 (1995): 919-924.
Chicago
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., KISS, R."COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS". International Journal of Oncology 6, no. 4 (1995): 919-924. https://doi.org/10.3892/ijo.6.4.919
Copy and paste a formatted citation
x
Spandidos Publications style
SALMON I, CRAS P, REMMELINK M, HENRION S, PASTEELS J, BROTCHI J and KISS R: COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS. Int J Oncol 6: 919-924, 1995.
APA
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., & KISS, R. (1995). COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS. International Journal of Oncology, 6, 919-924. https://doi.org/10.3892/ijo.6.4.919
MLA
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., KISS, R."COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS". International Journal of Oncology 6.4 (1995): 919-924.
Chicago
SALMON, I., CRAS, P., REMMELINK, M., HENRION, S., PASTEELS, J., BROTCHI, J., KISS, R."COMPUTER-ASSISTED QUANTITATIVE DESCRIPTION OF CHROMATIN PATTERN AND DNA-PLOIDY LEVEL IN EPENDYMOMAS AND CHOROID-PLEXUS TUMORS". International Journal of Oncology 6, no. 4 (1995): 919-924. https://doi.org/10.3892/ijo.6.4.919
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