VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS

  • Authors:
    • J MATTERN
    • R KOOMAGI
    • M VOLM
  • View Affiliations

  • Published online on: May 1, 1995     https://doi.org/10.3892/ijo.6.5.1059
  • Pages: 1059-1062
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Abstract

Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 204 cases (61%). Tumor vascularity was quantitatively assessed by microvessel counting after staining with the endothelial-specific marker factor VIII. The mean microvessel count for all patients was 9.6+/-10.4. Expression of VEGF was closely associated with increment of microvessel density. Postoperative follow-up of patients demonstrated a trend that survival time of patients with VEGF-positive tumors was worse than that of patients with VEGF-negative tumors. In contrast, microvessel density was not a prognostic factor.

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May 1995
Volume 6 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MATTERN J, KOOMAGI R and VOLM M: VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS. Int J Oncol 6: 1059-1062, 1995
APA
MATTERN, J., KOOMAGI, R., & VOLM, M. (1995). VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS. International Journal of Oncology, 6, 1059-1062. https://doi.org/10.3892/ijo.6.5.1059
MLA
MATTERN, J., KOOMAGI, R., VOLM, M."VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS". International Journal of Oncology 6.5 (1995): 1059-1062.
Chicago
MATTERN, J., KOOMAGI, R., VOLM, M."VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS". International Journal of Oncology 6, no. 5 (1995): 1059-1062. https://doi.org/10.3892/ijo.6.5.1059