COEXPRESSION OF C-ERBB2 AND INT-2 ONCOGENES IN INVASIVE BREAST-CANCER

  • Authors:
    • SM ELGENDY
    • Q TAHIN
    • M ELMERZABANI
    • AA ELAASER
    • NJ BARNABAS
    • J RUSSO
  • View Affiliations

  • Published online on: May 1, 1995     https://doi.org/10.3892/ijo.6.5.977
  • Pages: 977-984
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Abstract

Invasive breast carcinomas of 19 premenopausal and 49 postmenopausal women were studied by Southern blot analysis for detection of c-erbB2 and int-2 oncogenes, and quantitation of c-erbB2 protein, p185 by ELISA. The data were correlated with the histological grade of the tumor and the patient's clinical status. Seventeen tumors (25.0%) showed genomic alteration in one or both oncogenes. c-erbB2 and int-2 amplification were expressed by 10 (14.7%) and 7 (10.2%) of the tumors respectively. c-erbB2 overexpression was found in 15 out of 68 tumors (22.1%). All tumors exhibiting amplification of c-erbB2 also showed overexpression of p185 protein, however 5 out of 15 tumors (33.3%) showing c-erbB2 overexpression did not show amplification. Rearrangement of c-erbB2 and int-2 oncogenes was observed in 4 out of 68 tumors (5.9%) and 2 of these tumors presented rearrangement of both oncogenes. A significant positive correlation was found between c-erbB2 amplification and p185 protein overexpression, and c-erbB2 and int-2 amplification. Oncogene alterations were more frequently detected in tumors with high histological grade, but no correlation was found with patient's age, menopausal or lymph node status.

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May 1995
Volume 6 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ELGENDY S, TAHIN Q, ELMERZABANI M, ELAASER A, BARNABAS N and RUSSO J: COEXPRESSION OF C-ERBB2 AND INT-2 ONCOGENES IN INVASIVE BREAST-CANCER. Int J Oncol 6: 977-984, 1995.
APA
ELGENDY, S., TAHIN, Q., ELMERZABANI, M., ELAASER, A., BARNABAS, N., & RUSSO, J. (1995). COEXPRESSION OF C-ERBB2 AND INT-2 ONCOGENES IN INVASIVE BREAST-CANCER. International Journal of Oncology, 6, 977-984. https://doi.org/10.3892/ijo.6.5.977
MLA
ELGENDY, S., TAHIN, Q., ELMERZABANI, M., ELAASER, A., BARNABAS, N., RUSSO, J."COEXPRESSION OF C-ERBB2 AND INT-2 ONCOGENES IN INVASIVE BREAST-CANCER". International Journal of Oncology 6.5 (1995): 977-984.
Chicago
ELGENDY, S., TAHIN, Q., ELMERZABANI, M., ELAASER, A., BARNABAS, N., RUSSO, J."COEXPRESSION OF C-ERBB2 AND INT-2 ONCOGENES IN INVASIVE BREAST-CANCER". International Journal of Oncology 6, no. 5 (1995): 977-984. https://doi.org/10.3892/ijo.6.5.977