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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1995 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1995 Volume 6 Issue 6

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Article

HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE

  • Authors:
    • R MAGGI
    • RM MORETTI
    • M Montagnani Marelli
    • F PIMPINELLI
    • M MOTTA

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 1231-1236
    |
    Published online on: June 1, 1995
       https://doi.org/10.3892/ijo.6.6.1231
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Abstract

Recent evidence suggests a direct antiproliferative effect of LHRH agonists on the prostatic carcinoma cell line LNCaP. In the present study the possible presence of a LHRH degrading activity (LHRH-DA) in soluble fractions of LNCaP cell homogenates has been investigated. The results obtained show that an LHRH-DA is present in the soluble fraction of LNCaP cells with apparent Km and Vmax values of 31.6 mu M and 4.5 pmol/min/mu g protein respectively. The degradation pattern of LHRH is characterized by two major initial degradation products identified as LHRH 1-5 and LHRH 1-6 fragments. The degradation of the tracer [pGlu-H-3]LHRH, used as a substrate, is inhibited by synthetic unlabelled LHRH (IC50 7.9 mu M) and by several LHRH agonists with different kinetics and potencies; the LHRH agonist [DSer-(tBu)(6),Gly(10)-Aza]LHRH was the most potent blocker of LHRH-DA present in LNCaP cells; this enzymatic activity is also inhibited in a dose dependent manner by somatostatin, TRH, bacitracin and dithiothreitol. The LHRH-DA present in the soluble fraction of LNCaP cells does not seem to be modified by the deprivation of steroids from the culture medium, In conclusion, the presence in LNCaP cells of a soluble peptidase able to degrade LHRH might reinforce the possibility that the prostate is a target for the action of LHRH and of LHRH analogs.

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Copy and paste a formatted citation
Spandidos Publications style
MAGGI R, MORETTI R, Montagnani Marelli M, PIMPINELLI F and MOTTA M: HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE. Int J Oncol 6: 1231-1236, 1995.
APA
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., & MOTTA, M. (1995). HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE. International Journal of Oncology, 6, 1231-1236. https://doi.org/10.3892/ijo.6.6.1231
MLA
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., MOTTA, M."HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE". International Journal of Oncology 6.6 (1995): 1231-1236.
Chicago
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., MOTTA, M."HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE". International Journal of Oncology 6, no. 6 (1995): 1231-1236. https://doi.org/10.3892/ijo.6.6.1231
Copy and paste a formatted citation
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Spandidos Publications style
MAGGI R, MORETTI R, Montagnani Marelli M, PIMPINELLI F and MOTTA M: HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE. Int J Oncol 6: 1231-1236, 1995.
APA
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., & MOTTA, M. (1995). HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE. International Journal of Oncology, 6, 1231-1236. https://doi.org/10.3892/ijo.6.6.1231
MLA
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., MOTTA, M."HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE". International Journal of Oncology 6.6 (1995): 1231-1236.
Chicago
MAGGI, R., MORETTI, R., Montagnani Marelli, M., PIMPINELLI, F., MOTTA, M."HUMAN PROSTATIC-CARCINOMA CELL-LINE LNCAP DEGRADES LUTEINIZING-HORMONE-RELEASING HORMONE". International Journal of Oncology 6, no. 6 (1995): 1231-1236. https://doi.org/10.3892/ijo.6.6.1231
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