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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1995 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1995 Volume 6 Issue 6

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PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR

  • Authors:
    • M ALAIBAC
    • R YU
    • AC CHU

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    Affiliations: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DERMATOL UNIT,LONDON,ENGLAND.
  • Pages: 1267-1270
    |
    Published online on: June 1, 1995
       https://doi.org/10.3892/ijo.6.6.1267
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Abstract

In this report, we describe the analysis of clonality performed using a PCR-based approach in a group of cutaneous T-cell lymphomas including a case of localised pagetoid reticulosis expressing the gamma delta T-cell receptor. For our PCR analysis DNA was extracted from frozen tissue of 10 cases of cutaneous T-cell lymphomas and subjected to polymerase chain reaction amplification using primers recognizing conserved sequences of the variable and joining regions of the T-cell receptor gamma chain gene. PCR products were then analyzed by high resolution non-denaturing polyacrylamide gel electrophoresis. Clonal TCR gamma gene rearrangements were detected in all the cases investigated including the case of localised pagetoid reticulosis. The PCR-based approach used in this study may provide an alternative to conventional Southern blot analysis for the analysis of cutaneous T-cell lymphomas as it is easy to perform and requires only minimal amounts of DNA. The findings in localized pagetoid reticulosis are consistent with the proliferation of monoclonal T-cells in lesional skin of this condition and provide evidence for the lymphoproliferative nature of this clinically benign disorder.

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Copy and paste a formatted citation
Spandidos Publications style
ALAIBAC M, YU R and CHU A: PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR. Int J Oncol 6: 1267-1270, 1995.
APA
ALAIBAC, M., YU, R., & CHU, A. (1995). PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR. International Journal of Oncology, 6, 1267-1270. https://doi.org/10.3892/ijo.6.6.1267
MLA
ALAIBAC, M., YU, R., CHU, A."PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR". International Journal of Oncology 6.6 (1995): 1267-1270.
Chicago
ALAIBAC, M., YU, R., CHU, A."PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR". International Journal of Oncology 6, no. 6 (1995): 1267-1270. https://doi.org/10.3892/ijo.6.6.1267
Copy and paste a formatted citation
x
Spandidos Publications style
ALAIBAC M, YU R and CHU A: PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR. Int J Oncol 6: 1267-1270, 1995.
APA
ALAIBAC, M., YU, R., & CHU, A. (1995). PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR. International Journal of Oncology, 6, 1267-1270. https://doi.org/10.3892/ijo.6.6.1267
MLA
ALAIBAC, M., YU, R., CHU, A."PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR". International Journal of Oncology 6.6 (1995): 1267-1270.
Chicago
ALAIBAC, M., YU, R., CHU, A."PCR DETECTION OF CLONAL TCR GAMMA-GENE REARRANGEMENTS IN A GROUP OF CUTANEOUS T-CELL LYMPHOMAS INCLUDING A CASE OF LOCALIZED PAGETOID RETICULOSIS EXPRESSING THE GAMMA-DELTA TCR". International Journal of Oncology 6, no. 6 (1995): 1267-1270. https://doi.org/10.3892/ijo.6.6.1267
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