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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1995 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 7 Issue 1

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Article

MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE

  • Authors:
    • SW WANG
    • DD BOYD

  • View Affiliations / Copyright

    Affiliations: MD ANDERSON CANC CTR, DEPT TUMOR BIOL & HEAD & NECK SURG, HOUSTON, TX 77030 USA.
  • Pages: 143-146
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/ijo.7.1.143
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Abstract

The urokinase-type plasminogen activator contributes to the invasive phenotype of tumor cells by facilitating extracellular matrix hydrolysis. However, the molecular mechanism(s) responsible for urokinase overexpression remains unclear. The current study was undertaken to determine the role of the p53 tumor suppressor gene in the regulation of urokinase expression. Transient cob transfection of a urokinase-producing cell line with a wildtype p53 expression vector and a CAT reporter driven by the urokinase promoter led to a dramatic reduction in CAT activity. Conversely, urokinase promoter activity was increased in cells transiently transfected with a p53 expression vector mutated at codon 175. To determine if the endogenous urokinase gene was modulated by p53, cells were stably transfected with a mutated p53-bearing expression vector. An increased level of urokinase mRNA was apparent in pooled mutant p53-overexpressing clones. These studies argue for a role of the p53 tumor suppressor gene in the regulation of urokinase expression.

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Copy and paste a formatted citation
Spandidos Publications style
WANG S and BOYD D: MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE. Int J Oncol 7: 143-146, 1995.
APA
WANG, S., & BOYD, D. (1995). MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE. International Journal of Oncology, 7, 143-146. https://doi.org/10.3892/ijo.7.1.143
MLA
WANG, S., BOYD, D."MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE". International Journal of Oncology 7.1 (1995): 143-146.
Chicago
WANG, S., BOYD, D."MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE". International Journal of Oncology 7, no. 1 (1995): 143-146. https://doi.org/10.3892/ijo.7.1.143
Copy and paste a formatted citation
x
Spandidos Publications style
WANG S and BOYD D: MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE. Int J Oncol 7: 143-146, 1995.
APA
WANG, S., & BOYD, D. (1995). MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE. International Journal of Oncology, 7, 143-146. https://doi.org/10.3892/ijo.7.1.143
MLA
WANG, S., BOYD, D."MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE". International Journal of Oncology 7.1 (1995): 143-146.
Chicago
WANG, S., BOYD, D."MODULATION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSION BY THE WILD-TYPE AND MUTATED P53 TUMOR-SUPPRESSOR GENE". International Journal of Oncology 7, no. 1 (1995): 143-146. https://doi.org/10.3892/ijo.7.1.143
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