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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1995 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 7 Issue 1

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Article

ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS

  • Authors:
    • H KIARIS
    • DA SPANDIDOS

  • View Affiliations / Copyright

    Affiliations: NATL HELLEN RES FND,INST BIOL RES & BIOTECHNOL,GR-16635 ATHENS,GREECE. UNIV CRETE,SCH MED,IRAKLION,GREECE.
  • Pages: 75-80
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/ijo.7.1.75
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Abstract

The levels of expression of the ras family genes, in 14 tumour specimens from squamous cell carcinomas of the larynx were analysed by reverse transcription-polymerase chain reaction. The H-ras was overexpressed in 12 (86%) samples, K-ras in 11 (78%) and N-ras in 8 (57%) samples. All tumours exhibited overexpression of at least one member of the I-as family. In addition, each member of the ras family was activated independently from the rest of the ras family genes. The incidence of amplification in the ms family genes was also analysed by differential PCR: K-rns was found amplified in 14% (2/14), N-ras in 7% (1/14) and H-ras in none of the samples tested. Amplification data exhibited no association with the expressional levels of the ras genes. Furthermore, we investigated the incidence of codon 12 point mutations in the ras family genes but no mutation was found. The present study indicates that overexpression of the ras family genes is important for the development of the disease and it is not associated with the amplification status of the genes. In addition, the differential regulation among the members of the ms family might play a role in the development of laryngeal tumours.

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Copy and paste a formatted citation
Spandidos Publications style
KIARIS H and SPANDIDOS D: ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS. Int J Oncol 7: 75-80, 1995.
APA
KIARIS, H., & SPANDIDOS, D. (1995). ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS. International Journal of Oncology, 7, 75-80. https://doi.org/10.3892/ijo.7.1.75
MLA
KIARIS, H., SPANDIDOS, D."ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS". International Journal of Oncology 7.1 (1995): 75-80.
Chicago
KIARIS, H., SPANDIDOS, D."ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS". International Journal of Oncology 7, no. 1 (1995): 75-80. https://doi.org/10.3892/ijo.7.1.75
Copy and paste a formatted citation
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Spandidos Publications style
KIARIS H and SPANDIDOS D: ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS. Int J Oncol 7: 75-80, 1995.
APA
KIARIS, H., & SPANDIDOS, D. (1995). ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS. International Journal of Oncology, 7, 75-80. https://doi.org/10.3892/ijo.7.1.75
MLA
KIARIS, H., SPANDIDOS, D."ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS". International Journal of Oncology 7.1 (1995): 75-80.
Chicago
KIARIS, H., SPANDIDOS, D."ANALYSIS OF H-RAS, K-RAS AND N-RAS GENES FOR EXPRESSION, MUTATION AND AMPLIFICATION IN LARYNGEAL TUMORS". International Journal of Oncology 7, no. 1 (1995): 75-80. https://doi.org/10.3892/ijo.7.1.75
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