ANTITUMOR-ACTIVITY AND DISTRIBUTION OF BETA-D-LACTOSYLISOPHOSPHORAMIDE MUSTARD - A POTENTIAL CYTOSTATIC AGENT EXPLOITING LECTIN MEDIATED TRANSPORT

  • Authors:
    • J STUBEN
    • B BERTRAM
    • M WIESSLER
  • View Affiliations

  • Published online on: August 1, 1995     https://doi.org/10.3892/ijo.7.2.225
  • Pages: 225-231
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Abstract

Affinity chromatography of the Walker carcinosarcoma 256 B tumor revealed a lactose-specific lectin of 24 kDa. In a chemotherapeutical experiment, B-D-lactosylisophosphoramide mustard (corresponding lectin present in tumor tissue) proved to be significantly more active than B-D-maltosylisophosphoramide mustard (no corresponding lectin present), although both compounds differ only marginally in their sugar parts. Whole body autoradiography after application of C-14-labeled B-D-lactosylisophosphoramide mustard in tumor bearing rats shows an accumulation of radioactivity in kidneys, thymus, central nervous system and in the tumor. Binding between the isolated lectin and the lactose-conjugated drug is shown in vitro; its activation outside tumor cells is experimentally excluded.

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August 1995
Volume 7 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
STUBEN J, BERTRAM B and WIESSLER M: ANTITUMOR-ACTIVITY AND DISTRIBUTION OF BETA-D-LACTOSYLISOPHOSPHORAMIDE MUSTARD - A POTENTIAL CYTOSTATIC AGENT EXPLOITING LECTIN MEDIATED TRANSPORT. Int J Oncol 7: 225-231, 1995
APA
STUBEN, J., BERTRAM, B., & WIESSLER, M. (1995). ANTITUMOR-ACTIVITY AND DISTRIBUTION OF BETA-D-LACTOSYLISOPHOSPHORAMIDE MUSTARD - A POTENTIAL CYTOSTATIC AGENT EXPLOITING LECTIN MEDIATED TRANSPORT. International Journal of Oncology, 7, 225-231. https://doi.org/10.3892/ijo.7.2.225
MLA
STUBEN, J., BERTRAM, B., WIESSLER, M."ANTITUMOR-ACTIVITY AND DISTRIBUTION OF BETA-D-LACTOSYLISOPHOSPHORAMIDE MUSTARD - A POTENTIAL CYTOSTATIC AGENT EXPLOITING LECTIN MEDIATED TRANSPORT". International Journal of Oncology 7.2 (1995): 225-231.
Chicago
STUBEN, J., BERTRAM, B., WIESSLER, M."ANTITUMOR-ACTIVITY AND DISTRIBUTION OF BETA-D-LACTOSYLISOPHOSPHORAMIDE MUSTARD - A POTENTIAL CYTOSTATIC AGENT EXPLOITING LECTIN MEDIATED TRANSPORT". International Journal of Oncology 7, no. 2 (1995): 225-231. https://doi.org/10.3892/ijo.7.2.225