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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1995 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1995 Volume 7 Issue 2

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Article

DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING

  • Authors:
    • GG SPENCER
    • DP WOOD
    • RC GUPTA

  • View Affiliations / Copyright

    Affiliations: UNIV KENTUCKY,GRAD CTR TOXICOL,DEPT PREVENT MED & ENVIRONM HLTH,LEXINGTON,KY 40506. UNIV KENTUCKY,GRAD CTR TOXICOL,DEPT UROL SURG,LEXINGTON,KY 40506.
  • Pages: 245-248
    |
    Published online on: August 1, 1995
       https://doi.org/10.3892/ijo.7.2.245
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Abstract

Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of male cancer deaths in the United States. Several risk factors have been identified for prostate cancer, including increased serum testosterone levels, dietary fat intake, and ethnicity. In attempts to detect DNA damage in prostate tissue, we examined in a pilot study 18 pairs (36 samples) of normal and tumorous tissue biopsies from patients ages 50-76 years. DNA was isolated from frozen tissue by solvent extractions with DNA yield ranging from 392-1925 mu g/g tissue (mean 849 +/- 339 mu g/g). Analysis of the DNA by the nuclease P1-mediated P-32-postlabeling assay revealed the presence of multiple adducts in all DNA samples, irrespective of whether the tissue was normal or tumorous. Adduct levels generally ranged from 1-34 (mean 8 +/- 8) per 10(9) nucleotides for normal tissue and 3-37 (mean 11 +/- 9) per 10(9) nucleotides for tumorous tissue. Our data suggest (i) accumulation of DNA adducts in both normal and tumorous tissues; (ii) chromatographic similarity of certain adducts; and (iii) on an average, somewhat higher adduct levels in tumorous than normal tissue. Due to the small sample size examined, it remains to be determined if these DNA adducts were related to any of the risk factors.

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Copy and paste a formatted citation
Spandidos Publications style
SPENCER G, WOOD D and GUPTA R: DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING. Int J Oncol 7: 245-248, 1995.
APA
SPENCER, G., WOOD, D., & GUPTA, R. (1995). DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING. International Journal of Oncology, 7, 245-248. https://doi.org/10.3892/ijo.7.2.245
MLA
SPENCER, G., WOOD, D., GUPTA, R."DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING". International Journal of Oncology 7.2 (1995): 245-248.
Chicago
SPENCER, G., WOOD, D., GUPTA, R."DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING". International Journal of Oncology 7, no. 2 (1995): 245-248. https://doi.org/10.3892/ijo.7.2.245
Copy and paste a formatted citation
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Spandidos Publications style
SPENCER G, WOOD D and GUPTA R: DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING. Int J Oncol 7: 245-248, 1995.
APA
SPENCER, G., WOOD, D., & GUPTA, R. (1995). DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING. International Journal of Oncology, 7, 245-248. https://doi.org/10.3892/ijo.7.2.245
MLA
SPENCER, G., WOOD, D., GUPTA, R."DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING". International Journal of Oncology 7.2 (1995): 245-248.
Chicago
SPENCER, G., WOOD, D., GUPTA, R."DETECTION OF DNA-ADDUCTS IN NORMAL AND TUMOROUS HUMAN PROSTATE BIOPSIES BY P-32 POSTLABELING". International Journal of Oncology 7, no. 2 (1995): 245-248. https://doi.org/10.3892/ijo.7.2.245
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