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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1995 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1995 Volume 7 Issue 2

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Article

DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION

  • Authors:
    • H TAMURA
    • A OKUDA
    • M OHTSU
    • M KABEMURA
    • G KIMURA

  • View Affiliations / Copyright

    Affiliations: KYUSHU UNIV 69,MED INST BIOREGULAT,DEPT VIROL,FUKUOKA 81282,JAPAN.
  • Pages: 273-278
    |
    Published online on: August 1, 1995
       https://doi.org/10.3892/ijo.7.2.273
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Abstract

We previously demonstrated that the efficiency of cell transformation by simian virus 40 (SV40) is reduced when proliferating rat 3Y1 cells are inoculated with SV40 as compared with when density-arrested cells are inoculated. In this study, we characterized in more detail the cellular state at the time of virus inoculation that affects the susceptibility to SV40 transformation. When density-arrested 3Y1 cells were stimulated to progress one round of cell cycle by refeeding with medium containing high serum, they began to reduce the susceptibility to SV40 transformation before entering S phase. After re-entry into the non-proliferative state, prolonged maintenance of cells in the non-proliferative state was necessary for restoration of the susceptibility to SV40 transformation. Such dependency of the transformation efficiency on the cellular state at the time of SV40 inoculation paralleled with that of the expression of T antigen in nuclei, while virus adsorption and degradation of the DNA of the adsorbed virus was not dependent on the cellular state. We conclude that after inoculation of proliferating cells with SV40, an unidentified event between the virus adsorption and the accumulation of T antigen protein in nuclei is blocked and that this blockage causes the inhibition of the initiation of transformation.

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Copy and paste a formatted citation
Spandidos Publications style
TAMURA H, OKUDA A, OHTSU M, KABEMURA M and KIMURA G: DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION. Int J Oncol 7: 273-278, 1995.
APA
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., & KIMURA, G. (1995). DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION. International Journal of Oncology, 7, 273-278. https://doi.org/10.3892/ijo.7.2.273
MLA
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., KIMURA, G."DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION". International Journal of Oncology 7.2 (1995): 273-278.
Chicago
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., KIMURA, G."DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION". International Journal of Oncology 7, no. 2 (1995): 273-278. https://doi.org/10.3892/ijo.7.2.273
Copy and paste a formatted citation
x
Spandidos Publications style
TAMURA H, OKUDA A, OHTSU M, KABEMURA M and KIMURA G: DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION. Int J Oncol 7: 273-278, 1995.
APA
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., & KIMURA, G. (1995). DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION. International Journal of Oncology, 7, 273-278. https://doi.org/10.3892/ijo.7.2.273
MLA
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., KIMURA, G."DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION". International Journal of Oncology 7.2 (1995): 273-278.
Chicago
TAMURA, H., OKUDA, A., OHTSU, M., KABEMURA, M., KIMURA, G."DEPENDENCY OF THE EFFICIENCY OF TRANSFORMATION BY SIMIAN-VIRUS-40 ON THE PROLIFERATIVE STATE OF CULTURED FIBROBLASTS AT THE TIME OF VIRUS INOCULATION". International Journal of Oncology 7, no. 2 (1995): 273-278. https://doi.org/10.3892/ijo.7.2.273
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