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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST

  • Authors:
    • EM TCHEVKINA
    • NP KISSELJOVA
    • MS SHTUTMAN
    • EA MUSATKINA
    • OA MIZENINA
    • KV LESKOV
    • A TAVITIAN
    • FL KISSELJOV

  • View Affiliations / Copyright

    Affiliations: CTR CANC RES,INST CARCINOGENESIS,MOSCOW,RUSSIA. INSERM,U248,F-75010 PARIS,FRANCE.
  • Pages: 453-459
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.453
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Abstract

Previously, it was shown that hamster cells transformed by Rous Sarcoma Virus (RSV) exhibited a decreased expression of the RSV products (including the pp60 src oncogene) when these cells were supertransfected with the N-ras oncogene. To assess the responsibility of the activated N-ras in the modulation of the RSV viral products, a strategy based on two ras antagonists was used; i.e. i) a rap1A/K-rev1 expression vector known for its capacity to revert the K-ras induced transformed phenotype and ii) a plasmid containing antisense N-ras sequence. We present data showing only the plasmid construct containing the N-ras antisense sequense could inhibit expression or N-ras and, at the same time, restore the expression of v-src, up to a level comparable to that of the parental cells. Our results support the idea that some biological switches, triggered and activated through the N-ras oncogene pathway, might modulate the promoter activity of the RSV LTR.

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Copy and paste a formatted citation
Spandidos Publications style
TCHEVKINA E, KISSELJOVA N, SHTUTMAN M, MUSATKINA E, MIZENINA O, LESKOV K, TAVITIAN A and KISSELJOV F: SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST. Int J Oncol 7: 453-459, 1995.
APA
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K. ... KISSELJOV, F. (1995). SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST. International Journal of Oncology, 7, 453-459. https://doi.org/10.3892/ijo.7.3.453
MLA
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K., TAVITIAN, A., KISSELJOV, F."SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST". International Journal of Oncology 7.3 (1995): 453-459.
Chicago
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K., TAVITIAN, A., KISSELJOV, F."SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST". International Journal of Oncology 7, no. 3 (1995): 453-459. https://doi.org/10.3892/ijo.7.3.453
Copy and paste a formatted citation
x
Spandidos Publications style
TCHEVKINA E, KISSELJOVA N, SHTUTMAN M, MUSATKINA E, MIZENINA O, LESKOV K, TAVITIAN A and KISSELJOV F: SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST. Int J Oncol 7: 453-459, 1995.
APA
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K. ... KISSELJOV, F. (1995). SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST. International Journal of Oncology, 7, 453-459. https://doi.org/10.3892/ijo.7.3.453
MLA
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K., TAVITIAN, A., KISSELJOV, F."SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST". International Journal of Oncology 7.3 (1995): 453-459.
Chicago
TCHEVKINA, E., KISSELJOVA, N., SHTUTMAN, M., MUSATKINA, E., MIZENINA, O., LESKOV, K., TAVITIAN, A., KISSELJOV, F."SUPPRESSION AND RESTORATION OF V-SRC EXPRESSION IN RSV TRANSFORMED-CELLS AFTER TRANSFECTION WITH N-RAS AND ITS ANTAGONIST". International Journal of Oncology 7, no. 3 (1995): 453-459. https://doi.org/10.3892/ijo.7.3.453
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