search button

POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION

  • Authors:
    • A DE
    • N BOYADJIEVA
    • MG PASTORCIC
    • DK SARKAR

  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.643
  • Pages: 643-648
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The effect of alcohol on estrogen-regulated lactotropic cell proliferation was examined in Fisher 344 rats. Alcohol was administered for 2 weeks using liquid diet containing 8.7% ethanol (v/v) and 37% ethanol-derived calories. The control group was pair-fed with an isocaloric diet minus the ethanol or adlib-fed with normal diet. Ethanol-treated rats showed mean blood ethanol concentrations between 60-90 mg/dl. Alcohol treatment did not effect the body growth rate, but increased the DNA synthesis in lactotropes and reduced the levels of lactotropic growth inhibitory transforming growth factor-beta 1 (TGF-beta 1) protein and mRNA in the pituitary. These results suggest that alcohol promotes estrogen-induced lactotropic proliferation, possibly by down regulating the inhibitory TGF-beta 1 control of lactotropic function.

Related Articles

Journal Cover

September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
DE A, BOYADJIEVA N, PASTORCIC M and SARKAR D: POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION. Int J Oncol 7: 643-648, 1995
APA
DE, A., BOYADJIEVA, N., PASTORCIC, M., & SARKAR, D. (1995). POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION. International Journal of Oncology, 7, 643-648. https://doi.org/10.3892/ijo.7.3.643
MLA
DE, A., BOYADJIEVA, N., PASTORCIC, M., SARKAR, D."POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION". International Journal of Oncology 7.3 (1995): 643-648.
Chicago
DE, A., BOYADJIEVA, N., PASTORCIC, M., SARKAR, D."POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION". International Journal of Oncology 7, no. 3 (1995): 643-648. https://doi.org/10.3892/ijo.7.3.643