IN-VIVO EFFECT OF THE COMBINATION OF TNF AND ADRIAMYCIN AGAINST A HUMAN BREAST CELL-LINE EXPRESSING THE MDR-PHENOTYPE

  • Authors:
    • A ZYAD
    • ZZ CAI
    • J MORIZET
    • LG LEGRES
    • J BENARD
    • S CHOUAIB
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1067
  • Pages: 1067-1072
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Abstract

The combined effect of tumor necrosis factor alpha (TNF) and adriamycin (ADR) on tumor cell killing was investigated in vivo. The human breast adenocarcinoma ADR-resistant MDA/ADR cells found to be resistant to in vitro TNF lysis and with an apparent index of resistance to ADR of 23 have been used. Treatment of MDA/ADR subcutaneous tumor bearing mice with PBS, TNF, ADR or the combination of TNF/ADR indicate that the combination of TNF and ADR treatment leads to a significant decrease in tumor growth while treatment with TNF was inactive and treatment with ADR was moderately active. Tumor cells were collected from mice treated with TNF/ADR combination and analysed by PCR for MnSOD and TNF ne expression. No induction of the expression of these genes, known to be involved in the regulation of TNF-induced cell killing, was noted following TNF/ADR combination treatment, suggesting that their products were not involved in the observed resistance.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ZYAD A, CAI Z, MORIZET J, LEGRES L, BENARD J and CHOUAIB S: IN-VIVO EFFECT OF THE COMBINATION OF TNF AND ADRIAMYCIN AGAINST A HUMAN BREAST CELL-LINE EXPRESSING THE MDR-PHENOTYPE. Int J Oncol 7: 1067-1072, 1995
APA
ZYAD, A., CAI, Z., MORIZET, J., LEGRES, L., BENARD, J., & CHOUAIB, S. (1995). IN-VIVO EFFECT OF THE COMBINATION OF TNF AND ADRIAMYCIN AGAINST A HUMAN BREAST CELL-LINE EXPRESSING THE MDR-PHENOTYPE. International Journal of Oncology, 7, 1067-1072. https://doi.org/10.3892/ijo.7.5.1067
MLA
ZYAD, A., CAI, Z., MORIZET, J., LEGRES, L., BENARD, J., CHOUAIB, S."IN-VIVO EFFECT OF THE COMBINATION OF TNF AND ADRIAMYCIN AGAINST A HUMAN BREAST CELL-LINE EXPRESSING THE MDR-PHENOTYPE". International Journal of Oncology 7.5 (1995): 1067-1072.
Chicago
ZYAD, A., CAI, Z., MORIZET, J., LEGRES, L., BENARD, J., CHOUAIB, S."IN-VIVO EFFECT OF THE COMBINATION OF TNF AND ADRIAMYCIN AGAINST A HUMAN BREAST CELL-LINE EXPRESSING THE MDR-PHENOTYPE". International Journal of Oncology 7, no. 5 (1995): 1067-1072. https://doi.org/10.3892/ijo.7.5.1067