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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 7 Issue 5

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IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT

  • Authors:
    • BA GOUYON
    • F REYLDESMARS
    • M LEROMANCER
    • C PIGEON
    • MJM LEWIN
    • T LEHY

  • View Affiliations / Copyright

    Affiliations: HOP BICHAT,INSERM,UNITE GASTROENTEROL 10,F-75877 PARIS 18,FRANCE.
  • Pages: 1167-1173
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1167
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Abstract

The effect of somatostatin analogue, lanreotide, and bombesin/GRP antagonist, BIM 26226, on the growth of colon cancer peritoneal carcinomatosis in the rat was studied. BDIX rats were i.p. injected with DHD/K12 rat colon cancer cells at day 0 and received from day 3 either lanreotide, BIM 26226, combination of treatments or peptide solvents. At sacrifice, an day 45, no significant difference between groups was observed for peritoneal tumor growth, hepatic metastases, ascite volume and labeling indices in normal colonic mucosa and tumoral tissues. Survival times were similar in other lanreotide-treated and control groups. However, BIM 26226 decreased plasma gastrin level, consistently with a physiological effect of this peptide. Ln all groups, somatostatin and bombesin receptors were found on mucosal and tumoral tissues. Interestingly, bombesin receptor number was higher in severe than in minor cancer stages, contrarily to that of somatostatin receptors. Moreover, an up-regulation of somatostatin and bombesin receptors was observed in BIM 26226- and lanreotide-treated group tumors, respectively, Despite the presence of these specific receptors, lanreotide and BIM 26226 were inactive on tumor growth in this model.

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Copy and paste a formatted citation
Spandidos Publications style
GOUYON B, REYLDESMARS F, LEROMANCER M, PIGEON C, LEWIN M and LEHY T: IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT. Int J Oncol 7: 1167-1173, 1995.
APA
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., & LEHY, T. (1995). IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT. International Journal of Oncology, 7, 1167-1173. https://doi.org/10.3892/ijo.7.5.1167
MLA
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., LEHY, T."IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT". International Journal of Oncology 7.5 (1995): 1167-1173.
Chicago
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., LEHY, T."IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT". International Journal of Oncology 7, no. 5 (1995): 1167-1173. https://doi.org/10.3892/ijo.7.5.1167
Copy and paste a formatted citation
x
Spandidos Publications style
GOUYON B, REYLDESMARS F, LEROMANCER M, PIGEON C, LEWIN M and LEHY T: IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT. Int J Oncol 7: 1167-1173, 1995.
APA
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., & LEHY, T. (1995). IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT. International Journal of Oncology, 7, 1167-1173. https://doi.org/10.3892/ijo.7.5.1167
MLA
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., LEHY, T."IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT". International Journal of Oncology 7.5 (1995): 1167-1173.
Chicago
GOUYON, B., REYLDESMARS, F., LEROMANCER, M., PIGEON, C., LEWIN, M., LEHY, T."IN-VIVO EFFECT OF SOMATOSTATIN ANALOG, LANREOTIDE, AND/OR GRP ANTAGONIST, BIM-26226, ON THE GROWTH OF COLON-CANCER PERITONEAL CARCINOMATOSIS IN THE RAT". International Journal of Oncology 7, no. 5 (1995): 1167-1173. https://doi.org/10.3892/ijo.7.5.1167
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