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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 7 Issue 5

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Article

N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION

  • Authors:
    • C AVIGNOLO
    • S NIGRO
    • E GEIDO
    • W GIARETTI

  • View Affiliations / Copyright

    Affiliations: IST NAZL RIC CANC,IST,BIOPHYS & CYTOMETRY LAB,I-16132 GENOA,ITALY.
  • Pages: 1213-1217
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1213
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Abstract

N-(4-Hydroxyphenyl)retinamide (HPR) is a synthetic retinoid with anticancer properties and lower toxicity than all-trans retinoic acid (RA). We have studied the effects of HPR on apoptosis and differentiation in the human promyelocytic leukemia HL-60 cell line. In addition, we have tested the hypothesis that vimentin expression after HPR and RA, taken as indirect evidence of the mechanisms of action of the two retinoids, may be different. Quantitative evaluation of the percentage of apoptotic cells was carried out on a cell by cell basis by the flow cytometric DNA-content in situ-terminal-deoxynucleotydil-transferase (TdT assay). HPR was found to clearly induce apoptosis, while RA: instead, induced differentiation without apoptosis. These data confirm previous observations. Vimentin protein content was evaluated by flow cytometry with use of monoclonal antibodies simultaneously with DNA content. We found that HPR treated apoptotic cells were characterized by negative vimentin expression, while the HPR treated non apoptotic cells had about the same level of vimentin as the RA treated cells. These latter findings suggest that HPR may induce a functional effect (apoptosis) by a mechanism of action different from that of RA. Further work is necessary to clarify this finding.

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Copy and paste a formatted citation
Spandidos Publications style
AVIGNOLO C, NIGRO S, GEIDO E and GIARETTI W: N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION. Int J Oncol 7: 1213-1217, 1995.
APA
AVIGNOLO, C., NIGRO, S., GEIDO, E., & GIARETTI, W. (1995). N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION. International Journal of Oncology, 7, 1213-1217. https://doi.org/10.3892/ijo.7.5.1213
MLA
AVIGNOLO, C., NIGRO, S., GEIDO, E., GIARETTI, W."N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION". International Journal of Oncology 7.5 (1995): 1213-1217.
Chicago
AVIGNOLO, C., NIGRO, S., GEIDO, E., GIARETTI, W."N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION". International Journal of Oncology 7, no. 5 (1995): 1213-1217. https://doi.org/10.3892/ijo.7.5.1213
Copy and paste a formatted citation
x
Spandidos Publications style
AVIGNOLO C, NIGRO S, GEIDO E and GIARETTI W: N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION. Int J Oncol 7: 1213-1217, 1995.
APA
AVIGNOLO, C., NIGRO, S., GEIDO, E., & GIARETTI, W. (1995). N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION. International Journal of Oncology, 7, 1213-1217. https://doi.org/10.3892/ijo.7.5.1213
MLA
AVIGNOLO, C., NIGRO, S., GEIDO, E., GIARETTI, W."N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION". International Journal of Oncology 7.5 (1995): 1213-1217.
Chicago
AVIGNOLO, C., NIGRO, S., GEIDO, E., GIARETTI, W."N-(4-HYDROXYPHENYL)RETINAMIDE INDUCES APOPTOSIS IN HUMAN LEUKEMIA HL-60 CELLS AND MEDIATES VIMENTIN DOWN-REGULATION". International Journal of Oncology 7, no. 5 (1995): 1213-1217. https://doi.org/10.3892/ijo.7.5.1213
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