Identification of differentially expressed genes in breast cancer

Burger,A; Li,H; Panayiotakis,A; Salesiotis,A; Seth,A

doi:10.3892/ijo.8.2.395

Identification of differentially expressed genes in breast cancer

Authors:
- A Burger
- H Li
- A Panayiotakis
- A Salesiotis
- A Seth
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Affiliations: UNIV TORONTO,DEPT PATHOL,FAC MED,TORONTO,ON,CANADA. UNIV TORONTO,FAC DENT,TORONTO,ON,CANADA. UNIV TORONTO,WOMENS COLL HOSP,TORONTO,ON,CANADA. UNIV BRADFORD,CLIN ONCOL UNIT,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY. NCI,MOLEC ONCOL LAB,FREDERICK,MD.
Published online on: February 1, 1996 https://doi.org/10.3892/ijo.8.2.395
Pages: 395-400

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Abstract

A number of genes differentially expressed in breast cancer were isolated using a subtractive cloning technique. DNA sequence analysis and GenBank searches of T4F10, T2H7, and T2E5 cDNA clones found them to be identical with E2A, MSS1, and SEC13R genes. Their expression in a variety of primary breast tumor and cancer cell lines was compared with c-ERB-B2 and pS2 by Northern blot analysis. In breast cancer cell lines, the genes that we isolated are more frequently expressed than the previously described c-ERB-B2 and pS2.