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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
March 1996 Volume 8 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1996 Volume 8 Issue 3

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Article

Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells

  • Authors:
    • A Gualandris
    • M Rusnati
    • M Belleri
    • M Molinari-Tosatti
    • F Bonardi
    • A Albini
    • M Ziche
    • M Presta

  • View Affiliations / Copyright

    Affiliations: UNIV BRESCIA,DEPT BIOMED SCI & BIOTECHNOL,UNIT GEN PATHOL & IMMUNOL,I-25123 BRESCIA,ITALY. UNIV BRESCIA,DEPT BIOMED SCI & BIOTECHNOL,UNIT HISTOL,I-25123 BRESCIA,ITALY. IST NAZL RIC CANC,I-16132 GENOA,ITALY. UNIV FLORENCE,DEPT PHARMACOL,I-50134 FLORENCE,ITALY.
  • Pages: 567-573
    |
    Published online on: March 1, 1996
       https://doi.org/10.3892/ijo.8.3.567
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Abstract

Basic fibroblast growth factor (bFGF) is expressed in the vascular endothelium of human brain tumors. To investigate the biological consequences of a possible autocrine modality of microvascular endothelial cell activation by endogenous bFGF in these tumors, mouse brain microvascular endothelial cells were stably transfected with a retroviral expression vector harboring a human bFGF cDNA. When grown on tissue culture plastic, bFGF-transfected clones show a transformed morphology and increased saturation density. bFGF-transfectants have an invasive behavior when seeded on three-dimensional fibrin gel and originate endothelial cell sprouts when embedded within fibrin. Also, bFGF-transfected cells undergo morphogenetic organization and produce a complex network of branching cord-like structures connecting foci of infiltrating cells when seeded on Matrigel, a laminin-rich extracellular matrix material. In contrast, parental and mock-transfected cells do not invade fibrin gels nor organize on Matrigel. These findings demonstrate that bFGF overexpression induces an angiogenic phenotype in brain microvascular endothelial cells characterized by an invasive behavior and morphogenic potential. They support the notion that neovascularization of brain tumors can be triggered by stimuli that induce vascular endothelium to produce its own autocrine factor(s).

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Copy and paste a formatted citation
Spandidos Publications style
Gualandris A, Rusnati M, Belleri M, Molinari-Tosatti M, Bonardi F, Albini A, Ziche M and Presta M: Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells. Int J Oncol 8: 567-573, 1996.
APA
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A. ... Presta, M. (1996). Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells. International Journal of Oncology, 8, 567-573. https://doi.org/10.3892/ijo.8.3.567
MLA
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A., Ziche, M., Presta, M."Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells". International Journal of Oncology 8.3 (1996): 567-573.
Chicago
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A., Ziche, M., Presta, M."Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells". International Journal of Oncology 8, no. 3 (1996): 567-573. https://doi.org/10.3892/ijo.8.3.567
Copy and paste a formatted citation
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Spandidos Publications style
Gualandris A, Rusnati M, Belleri M, Molinari-Tosatti M, Bonardi F, Albini A, Ziche M and Presta M: Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells. Int J Oncol 8: 567-573, 1996.
APA
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A. ... Presta, M. (1996). Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells. International Journal of Oncology, 8, 567-573. https://doi.org/10.3892/ijo.8.3.567
MLA
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A., Ziche, M., Presta, M."Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells". International Journal of Oncology 8.3 (1996): 567-573.
Chicago
Gualandris, A., Rusnati, M., Belleri, M., Molinari-Tosatti, M., Bonardi, F., Albini, A., Ziche, M., Presta, M."Angiogenic phenotype induced by basic fibroblast growth factor transfection in brain microvascular endothelial cells". International Journal of Oncology 8, no. 3 (1996): 567-573. https://doi.org/10.3892/ijo.8.3.567
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