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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
March 1996 Volume 8 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 1996 Volume 8 Issue 3

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Article

Stereotactic radiosurgery for metastatic brain tumors

  • Authors:
    • M Chamberlain
    • P Kormanik
    • D Barba
    • B Fuller
    • D Smith
    • W Shea

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF SAN DIEGO,DEPT NURSING,LA JOLLA,CA 92093. UNIV CALIF SAN DIEGO,DEPT SURG,LA JOLLA,CA 92093. UNIV CALIF SAN DIEGO,DEPT RADIOL,LA JOLLA,CA 92093.
  • Pages: 617-624
    |
    Published online on: March 1, 1996
       https://doi.org/10.3892/ijo.8.3.617
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Abstract

We report on a prospective phase TI study utilizing stereotactic radiosurgery for patients with intracranial parenchymal metastases. Fifty patients ranging in age from 38 to 77 years with 1 to 3 intraparenchymal brain metastases were treated with stereotactic radiosurgery either immediately following whole brain radiotherapy or at the time of intracranial disease progression following failure of whole brain radiotherapy. Twenty patients treated with adjuvant therapy received a median radiosurgical dose of 20 Gy. Thirty patients treated with salvage therapy received a median radiosurgical dose of 20 Gy. No immediate neurotoxicity was seen following radiosurgery however, 4 patients (8%) developed symptomatic radiation necrosis. Median survival was 6.5 and 6.0 months for patients treated with adjuvant and salvage radiosurgery respectively. In patients with oligometastatic brain metastases manifesting intracranial disease progression after whole brain radiotherapy, salvage radiotherapy appears to offer improved palliation when compared to retreatment with whole brain radiotherapy. The results of patients treated with up-front adjuvant radiosurgery when compared to historical controls treated with whole brain radiotherapy only are less clear as to benefit and require a phase III study before definitive recommendations can be made.

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Copy and paste a formatted citation
Spandidos Publications style
Chamberlain M, Kormanik P, Barba D, Fuller B, Smith D and Shea W: Stereotactic radiosurgery for metastatic brain tumors. Int J Oncol 8: 617-624, 1996.
APA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., & Shea, W. (1996). Stereotactic radiosurgery for metastatic brain tumors. International Journal of Oncology, 8, 617-624. https://doi.org/10.3892/ijo.8.3.617
MLA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8.3 (1996): 617-624.
Chicago
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8, no. 3 (1996): 617-624. https://doi.org/10.3892/ijo.8.3.617
Copy and paste a formatted citation
x
Spandidos Publications style
Chamberlain M, Kormanik P, Barba D, Fuller B, Smith D and Shea W: Stereotactic radiosurgery for metastatic brain tumors. Int J Oncol 8: 617-624, 1996.
APA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., & Shea, W. (1996). Stereotactic radiosurgery for metastatic brain tumors. International Journal of Oncology, 8, 617-624. https://doi.org/10.3892/ijo.8.3.617
MLA
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8.3 (1996): 617-624.
Chicago
Chamberlain, M., Kormanik, P., Barba, D., Fuller, B., Smith, D., Shea, W."Stereotactic radiosurgery for metastatic brain tumors". International Journal of Oncology 8, no. 3 (1996): 617-624. https://doi.org/10.3892/ijo.8.3.617
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