Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease

Lorusso,V; Timurian,A; Brandi,M; Pellecchia,A; Cramarossa,A; Marzullo,F; deLena,M

doi:10.3892/ijo.8.4.669

April 1996 Volume 8 Issue 4

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April 1996 Volume 8 Issue 4

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Article

Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease

Authors:
- V Lorusso
- A Timurian
- M Brandi
- A Pellecchia
- A Cramarossa
- F Marzullo
- M deLena
View Affiliations / Copyright

Affiliations: INST ONCOL,MED ONCOL OPERAT UNIT,BARI,ITALY. INST ONCOL,RADIOTHERAPY UNIT,BARI,ITALY. INST ONCOL,ENDOSCOPY UNIT,BARI,ITALY. INST ONCOL,RADIOL UNIT,BARI,ITALY. INST ONCOL,PATHOL UNIT,BARI,ITALY.
Pages: 669-674
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Published online on: April 1, 1996

https://doi.org/10.3892/ijo.8.4.669
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Abstract

The aim of the study was to verify the possibility of treating patients with poor prognosis early-intermediate Hodgkin's disease with a combined modality therapy consisting of three cycles of ABVD followed by extended field irradiation (EFRT). No patient had bulky mediastinum or had previously been administered chemo- or radiotherapy. At pathological restaging, 40/44 (91%) evaluable patients achieved complete responses (CR). After a ten-year followup, freedom from progression (FFP), relapse-free survival (RFS) and overall survival (OS) were 80%, 83% and 81%, respectively. Of the prognostic factors, univariate analysis showed that only stage III negatively influenced RFS, but not OS. Toxicity was mild except for subclinical mediastinal fibrosis in 32.5% of CR patients. No patient reported reduced fertility. Two cases of second neoplasms were recorded: one ameboid glioma and one thymoma, both occurring within five years after discontinuing chemo-radiotherapy. Our data suggest that three cycles of ABVD preceeding EFRT is an effective treatment for poor prognosis early-intermediate stage Hodgkin's disease; nevertheless, stage III patients and some stage II patients with unfavorable prognostic factors should be treated with a more aggressive approach.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Three cycles of ABDV plus extended field radiotherapy in patients with poor prognosis early-intermediate stage Hodgkin's disease

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Abstract

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