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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1996 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 1996 Volume 8 Issue 5

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Article

MDM2 overexpression in benign and malignant lesions of the human breast

  • Authors:
    • D Baunoch
    • L Watkins
    • A Tewari
    • M Reece
    • L Adams
    • R Stack
    • A Brown
    • L Jones
    • D Christian
    • N Latif
    • W Lawrence
    • M Lane

  • View Affiliations / Copyright

    Affiliations: BAYSTATE MED CTR,OB GYN RES LABS,SPRINGFIELD,MA 01199. TUFTS UNIV,SCH MED,SPRINGFIELD,MA 01199. UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637. MICHIGAN CANC FDN,BREAST CANC PROGRAM,DETROIT,MI 48201. MICHIGAN CANC FDN,PROGRAM MOLEC BIOL,DETROIT,MI 48201. UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201.
  • Pages: 895-899
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/ijo.8.5.895
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Abstract

MDM2 overexpression has been detected in women with benign or cancerous lesions of the breast. Immunohistochemical methods were used to identify overexpression in 11 of 27 benign cases (41%) and 15 of 22 (68%) cancer cases. MDM2 overexpression correlated well with immunohistochemically detected estrogen receptor (ER), suggesting that expression of these proteins was coordinately regulated. To test this, the MCF-10A human breast cell line, negative for both ER and MDM2 expression, was transfected with a wild-type ER. Following transfection, both ER and MDM2 were strongly expressed in two independent clones. Expression of both was reduced in the presence of increasing concentrations of estradiol (10(-10)-10(-8) M) thus, estrogen may be involved in regulation of MDM2 expression in proliferative breast lesions.

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Copy and paste a formatted citation
Spandidos Publications style
Baunoch D, Watkins L, Tewari A, Reece M, Adams L, Stack R, Brown A, Jones L, Christian D, Latif N, Latif N, et al: MDM2 overexpression in benign and malignant lesions of the human breast. Int J Oncol 8: 895-899, 1996.
APA
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R. ... Lane, M. (1996). MDM2 overexpression in benign and malignant lesions of the human breast. International Journal of Oncology, 8, 895-899. https://doi.org/10.3892/ijo.8.5.895
MLA
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R., Brown, A., Jones, L., Christian, D., Latif, N., Lawrence, W., Lane, M."MDM2 overexpression in benign and malignant lesions of the human breast". International Journal of Oncology 8.5 (1996): 895-899.
Chicago
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R., Brown, A., Jones, L., Christian, D., Latif, N., Lawrence, W., Lane, M."MDM2 overexpression in benign and malignant lesions of the human breast". International Journal of Oncology 8, no. 5 (1996): 895-899. https://doi.org/10.3892/ijo.8.5.895
Copy and paste a formatted citation
x
Spandidos Publications style
Baunoch D, Watkins L, Tewari A, Reece M, Adams L, Stack R, Brown A, Jones L, Christian D, Latif N, Latif N, et al: MDM2 overexpression in benign and malignant lesions of the human breast. Int J Oncol 8: 895-899, 1996.
APA
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R. ... Lane, M. (1996). MDM2 overexpression in benign and malignant lesions of the human breast. International Journal of Oncology, 8, 895-899. https://doi.org/10.3892/ijo.8.5.895
MLA
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R., Brown, A., Jones, L., Christian, D., Latif, N., Lawrence, W., Lane, M."MDM2 overexpression in benign and malignant lesions of the human breast". International Journal of Oncology 8.5 (1996): 895-899.
Chicago
Baunoch, D., Watkins, L., Tewari, A., Reece, M., Adams, L., Stack, R., Brown, A., Jones, L., Christian, D., Latif, N., Lawrence, W., Lane, M."MDM2 overexpression in benign and malignant lesions of the human breast". International Journal of Oncology 8, no. 5 (1996): 895-899. https://doi.org/10.3892/ijo.8.5.895
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