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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1996 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1996 Volume 8 Issue 5

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Article

Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer

  • Authors:
    • Y Yonemura
    • Y Endou
    • T Yamaguchi
    • N Nojima
    • T Kawamura
    • T Fujimura
    • T Obata
    • B Kim
    • I Miyazaki
    • T Sasaki

  • View Affiliations / Copyright

    Affiliations: KANAZAWA UNIV,INST CANC RES,DEPT EXPTL THERAPEUT,KANAZAWA,ISHIKAWA 920,JAPAN. UNIV ULSAN,ASAN MED CTR,DEPT GEN SURG,ULSAN,SOUTH KOREA. KANAZAWA UNIV,SCH MED,DEPT ELECTRON MICROSCOPY,KANAZAWA,ISHIKAWA 920,JAPAN.
  • Pages: 925-931
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/ijo.8.5.925
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Abstract

To clarify the mechanisms of the metastasis on the peritoneal surface from gastric cancer, a novel ex vivo co-culture system using human greater omentum and a highly metastatic cell line, MKN-45-P was developed. MKN-45-P was established from a gastric cancer cell line of MKN-45 by the progressive growing of the intraperitoneal passages. The differences of the expression of metastasis related genes between MKN-45 and MKN-45-P were examined by RT-PCR. Cancer cells adhered only to the naked area of the submesothelial basement membrane, which was exposed by the shrinkage and exfoliation of mesothelial cells of the omentum. The expressions of integrin alpha 2 and alpha 3 subunits in MKN-45-P were extremely elevated compared to those in MKN-45. Integrin beta 1 subunit expression did not change during the intraperitoneal passages. Anti-beta 1 integrin subunit antibody significantly inhibited the adherent number of MKN-45-P on the omentum. These results indicate that VLA-2 and VLA-3 may have an important role in the formation of the peritoneal dissemination from gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yonemura Y, Endou Y, Yamaguchi T, Nojima N, Kawamura T, Fujimura T, Obata T, Kim B, Miyazaki I, Sasaki T, Sasaki T, et al: Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer. Int J Oncol 8: 925-931, 1996.
APA
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T. ... Sasaki, T. (1996). Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer. International Journal of Oncology, 8, 925-931. https://doi.org/10.3892/ijo.8.5.925
MLA
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T., Obata, T., Kim, B., Miyazaki, I., Sasaki, T."Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer". International Journal of Oncology 8.5 (1996): 925-931.
Chicago
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T., Obata, T., Kim, B., Miyazaki, I., Sasaki, T."Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer". International Journal of Oncology 8, no. 5 (1996): 925-931. https://doi.org/10.3892/ijo.8.5.925
Copy and paste a formatted citation
x
Spandidos Publications style
Yonemura Y, Endou Y, Yamaguchi T, Nojima N, Kawamura T, Fujimura T, Obata T, Kim B, Miyazaki I, Sasaki T, Sasaki T, et al: Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer. Int J Oncol 8: 925-931, 1996.
APA
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T. ... Sasaki, T. (1996). Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer. International Journal of Oncology, 8, 925-931. https://doi.org/10.3892/ijo.8.5.925
MLA
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T., Obata, T., Kim, B., Miyazaki, I., Sasaki, T."Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer". International Journal of Oncology 8.5 (1996): 925-931.
Chicago
Yonemura, Y., Endou, Y., Yamaguchi, T., Nojima, N., Kawamura, T., Fujimura, T., Obata, T., Kim, B., Miyazaki, I., Sasaki, T."Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer". International Journal of Oncology 8, no. 5 (1996): 925-931. https://doi.org/10.3892/ijo.8.5.925
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