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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1996 Volume 8 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1996 Volume 8 Issue 6

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Article

Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines

  • Authors:
    • C Papandreou
    • T Bogenrieder
    • H Scher
    • A Albino
    • D Nanus

  • View Affiliations / Copyright

    Affiliations: MEM SLOAN KETTERING CANC CTR,GENITOURINARY ONCOL RES LAB,NEW YORK,NY 10021. MEM SLOAN KETTERING CANC CTR,LAB MAMMALIAN CELL TRANSFORMAT,NEW YORK,NY 10021. MEM SLOAN KETTERING CANC CTR,DEPT MED,DIV SOLID TUMOR ONCOL,GENITOURINARY ONCOL SERV,NEW YORK,NY 10021. CORNELL UNIV,MED CTR,NEW YORK,NY 10021.
  • Pages: 1237-1241
    |
    Published online on: June 1, 1996
       https://doi.org/10.3892/ijo.8.6.1237
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Abstract

The SDI1/WAF1/CIP1 gene encodes a M(r) 21,000 protein (p21) that can arrest cell growth by associating with and inhibiting cyclin-dependent kinase complexes necessary for cells to exit G(1). It is a critical downstream effector in the p53 growth control pathway and can be transcriptionally upregulated by increasing levels of wild-type p53 protein. Somatic mutations in the p21 gene have been detected in 17% of primary prostate cancers. In the current study, we examined four prostate cancer cell lines for expression of and mutations in the p21 gene. Transcripts for p21 mRNA were present in all PC cell lines; p21 protein was detected in androgen-dependent LNCaP cells, as well as in androgen-independent DU-145 and TSU-Pr1 cells but not in androgen-independent PC-3 cells. Examination of the entire coding region of the p21 gene by SSCP analysis and direct DNA sequencing did not detect mutations in the coding domains of the p21 gene. These data indicate that mutations of the SDI1/WAF1/CIP1/p21 gene are not present in cultured PC cells and suggest that defects in the p21 gene are infrequent in prostate cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Papandreou C, Bogenrieder T, Scher H, Albino A and Nanus D: Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines. Int J Oncol 8: 1237-1241, 1996.
APA
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., & Nanus, D. (1996). Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines. International Journal of Oncology, 8, 1237-1241. https://doi.org/10.3892/ijo.8.6.1237
MLA
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., Nanus, D."Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines". International Journal of Oncology 8.6 (1996): 1237-1241.
Chicago
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., Nanus, D."Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines". International Journal of Oncology 8, no. 6 (1996): 1237-1241. https://doi.org/10.3892/ijo.8.6.1237
Copy and paste a formatted citation
x
Spandidos Publications style
Papandreou C, Bogenrieder T, Scher H, Albino A and Nanus D: Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines. Int J Oncol 8: 1237-1241, 1996.
APA
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., & Nanus, D. (1996). Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines. International Journal of Oncology, 8, 1237-1241. https://doi.org/10.3892/ijo.8.6.1237
MLA
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., Nanus, D."Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines". International Journal of Oncology 8.6 (1996): 1237-1241.
Chicago
Papandreou, C., Bogenrieder, T., Scher, H., Albino, A., Nanus, D."Expression and sequence analysis of the SDI1/WAF1/CIP1/p21 tumor suppressor gene in prostate cancer cell lines". International Journal of Oncology 8, no. 6 (1996): 1237-1241. https://doi.org/10.3892/ijo.8.6.1237
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