HER-2/neu, c-Myc and cyclin-A in human breast cancer

  • Authors:
    • S Tommasi
    • C Giannella
    • A Mangia
    • A Primavera
    • A Paradiso
    • F Schittulli
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/ijo.9.1.111
  • Pages: 111-115
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Abstract

To better understand the role of HER-2/neu, c-myc and cyclin-A which seem to be activated in different steps of tumor cell growth, we analyzed a series of breast cancers from patients subjected to radical mastectomy with regard to HER-2/neu amplification (N=171) and expression of HER-2/neu (N=114), c-myc (N=31) and cyclin-A (N=71). Molecular evaluation demonstrated that HER-2/neu was amplified in 20% of cases and overexpressed in 27%, and its alterations were associated with a higher proliferative activity (H-3-Tdr-labeling index), although not statistically significant in patients without lymph node metastases, c-myc was overexpressed in 16% of cases and was weakly correlated to proliferation activity. Cyclin-A was overexpressed in 15% of cases and was significantly correlated to the percentage of the H-3-Tdr labeled cell fraction (p=0.002). Cyclin-A alterations were also significantly associated with well-differentiated tumors, suggesting that this gene could be involved in the control of the normal cell cycle rather than to cell proliferation during tumor growth.

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July 1996
Volume 9 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tommasi S, Giannella C, Mangia A, Primavera A, Paradiso A and Schittulli F: HER-2/neu, c-Myc and cyclin-A in human breast cancer. Int J Oncol 9: 111-115, 1996
APA
Tommasi, S., Giannella, C., Mangia, A., Primavera, A., Paradiso, A., & Schittulli, F. (1996). HER-2/neu, c-Myc and cyclin-A in human breast cancer. International Journal of Oncology, 9, 111-115. https://doi.org/10.3892/ijo.9.1.111
MLA
Tommasi, S., Giannella, C., Mangia, A., Primavera, A., Paradiso, A., Schittulli, F."HER-2/neu, c-Myc and cyclin-A in human breast cancer". International Journal of Oncology 9.1 (1996): 111-115.
Chicago
Tommasi, S., Giannella, C., Mangia, A., Primavera, A., Paradiso, A., Schittulli, F."HER-2/neu, c-Myc and cyclin-A in human breast cancer". International Journal of Oncology 9, no. 1 (1996): 111-115. https://doi.org/10.3892/ijo.9.1.111