HER-2/neu, c-Myc and cyclin-A in human breast cancer

Tommasi,S; Giannella,C; Mangia,A; Primavera,A; Paradiso,A; Schittulli,F

doi:10.3892/ijo.9.1.111

July 1996 Volume 9 Issue 1

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July 1996 Volume 9 Issue 1

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Article

HER-2/neu, c-Myc and cyclin-A in human breast cancer

Authors:
- S Tommasi
- C Giannella
- A Mangia
- A Primavera
- A Paradiso
- F Schittulli
View Affiliations / Copyright

Affiliations: INST ONCOL,SURG SENOL,I-70126 BARI,ITALY.
Pages: 111-115
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Published online on: July 1, 1996

https://doi.org/10.3892/ijo.9.1.111
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Abstract

To better understand the role of HER-2/neu, c-myc and cyclin-A which seem to be activated in different steps of tumor cell growth, we analyzed a series of breast cancers from patients subjected to radical mastectomy with regard to HER-2/neu amplification (N=171) and expression of HER-2/neu (N=114), c-myc (N=31) and cyclin-A (N=71). Molecular evaluation demonstrated that HER-2/neu was amplified in 20% of cases and overexpressed in 27%, and its alterations were associated with a higher proliferative activity (H-3-Tdr-labeling index), although not statistically significant in patients without lymph node metastases, c-myc was overexpressed in 16% of cases and was weakly correlated to proliferation activity. Cyclin-A was overexpressed in 15% of cases and was significantly correlated to the percentage of the H-3-Tdr labeled cell fraction (p=0.002). Cyclin-A alterations were also significantly associated with well-differentiated tumors, suggesting that this gene could be involved in the control of the normal cell cycle rather than to cell proliferation during tumor growth.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

HER-2/neu, c-Myc and cyclin-A in human breast cancer

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Abstract

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