Human papillomaviruses (HPV) are associated with multiple myeloma

  • Authors:
    • D Payne
    • S Tyring
    • S Kumar
    • B Patten
    • B Shoaib
    • T Chan
  • View Affiliations

  • Published online on: August 1, 1996     https://doi.org/10.3892/ijo.9.2.345
  • Pages: 345-349
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Abstract

Human papillomaviruses (HPV) are small DNA tumor viruses, and are associated with epithelial neoplasias. Although HPV are believed to be exclusively permissive in terminally differentiated squamous cells, we have previously identified HPV sequences in lymphoid tissues of five patients. Because this result suggested that the range of the host virus cells could include cells of lymphoid origin, we used PCR and in situ hybridization to analyze nonepithelial tissues of patients with multiple myeloma from two institutions. A statistically significant association was established between HPV and multiple myeloma (p<0.001). This study supports the hypothesis that HPV can infect lymphoid cells.

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August 1996
Volume 9 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Payne D, Tyring S, Kumar S, Patten B, Shoaib B and Chan T: Human papillomaviruses (HPV) are associated with multiple myeloma. Int J Oncol 9: 345-349, 1996
APA
Payne, D., Tyring, S., Kumar, S., Patten, B., Shoaib, B., & Chan, T. (1996). Human papillomaviruses (HPV) are associated with multiple myeloma. International Journal of Oncology, 9, 345-349. https://doi.org/10.3892/ijo.9.2.345
MLA
Payne, D., Tyring, S., Kumar, S., Patten, B., Shoaib, B., Chan, T."Human papillomaviruses (HPV) are associated with multiple myeloma". International Journal of Oncology 9.2 (1996): 345-349.
Chicago
Payne, D., Tyring, S., Kumar, S., Patten, B., Shoaib, B., Chan, T."Human papillomaviruses (HPV) are associated with multiple myeloma". International Journal of Oncology 9, no. 2 (1996): 345-349. https://doi.org/10.3892/ijo.9.2.345