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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1996 Volume 9 Issue 3

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Article

Telomerase activity in human intestine

  • Authors:
    • E Hiyama
    • N Tatsumoto
    • T Kodama
    • K Hiyama
    • J Shay
    • T Yokoyama

  • View Affiliations / Copyright

    Affiliations: HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 2,MINAMI KU,HIROSHIMA 734,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT SURG 1,MINAMI KU,HIROSHIMA 734,JAPAN. UNIV TEXAS,SW MED CTR,DEPT CELL BIOL & NEUROSCI,DALLAS,TX 75235.
  • Pages: 453-458
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.453
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Abstract

In human somatic cells without the activity of telomerase, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode with each cell division. In germline and immortal cells telomerase activity maintains telomere length and thus compensates for the 'end-replication problem'. Progressive telomere shortening and reactivation of telomerase activity have been considered to be one of the key mechanisms in cellular senescence and immortalization. It has been shown that while most somatic cells do not have detectable telomerase activity, almost all cancers do have telomerase activity. Thus, detection of telomerase activity may have utility in the early diagnosis of cancer and may be a new target for therapeutic intervention. However, there is recent evidence that some cells of renewal tissues, such as hematopoietic cells and basal cells of the epidermis, have detectable telomerase activity. In the present study, we report detectable telomerase activity in normal human intestinal mucosa. This activity is localized to the lower third of each crypt and may be derived from intestinal stem cells. Since intestinal telomeric repeats are shorter in adults when compared to children, the telomerase activity in the intestine is insufficient to maintain telomere length but may be sufficient to provide extended proliferative capacity for such renewal tissues.

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Copy and paste a formatted citation
Spandidos Publications style
Hiyama E, Tatsumoto N, Kodama T, Hiyama K, Shay J and Yokoyama T: Telomerase activity in human intestine. Int J Oncol 9: 453-458, 1996.
APA
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., & Yokoyama, T. (1996). Telomerase activity in human intestine. International Journal of Oncology, 9, 453-458. https://doi.org/10.3892/ijo.9.3.453
MLA
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., Yokoyama, T."Telomerase activity in human intestine". International Journal of Oncology 9.3 (1996): 453-458.
Chicago
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., Yokoyama, T."Telomerase activity in human intestine". International Journal of Oncology 9, no. 3 (1996): 453-458. https://doi.org/10.3892/ijo.9.3.453
Copy and paste a formatted citation
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Spandidos Publications style
Hiyama E, Tatsumoto N, Kodama T, Hiyama K, Shay J and Yokoyama T: Telomerase activity in human intestine. Int J Oncol 9: 453-458, 1996.
APA
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., & Yokoyama, T. (1996). Telomerase activity in human intestine. International Journal of Oncology, 9, 453-458. https://doi.org/10.3892/ijo.9.3.453
MLA
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., Yokoyama, T."Telomerase activity in human intestine". International Journal of Oncology 9.3 (1996): 453-458.
Chicago
Hiyama, E., Tatsumoto, N., Kodama, T., Hiyama, K., Shay, J., Yokoyama, T."Telomerase activity in human intestine". International Journal of Oncology 9, no. 3 (1996): 453-458. https://doi.org/10.3892/ijo.9.3.453
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