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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 1996 Volume 9 Issue 3

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Article

Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas

  • Authors:
    • M Maxwell
    • T Galanopoulos
    • H Antoniades

  • View Affiliations / Copyright

    Affiliations: HARVARD UNIV,SCH MED,BOSTON,MA 02114. HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115. HARVARD UNIV,SCH PUBL HLTH,CTR BLOOD RES,BOSTON,MA 02115. UNIV OXFORD,RADCLIFFE INFIRM,DEPT NEUROPATHOL,OXFORD OX2 6HE,ENGLAND.
  • Pages: 493-497
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.493
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Abstract

Gliomas are malignant brain tumors thought to arise through multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cyclin D1 gene encodes a proto-oncogenic cell cycle regulator implicated in the pathogenesis of several types of cancer, including gliomas. Northern blot analysis revealed expression of cyclin D1 mRNA in 7 (47%) of 15 primary glioma specimens. Immunohistochemistry using an antibody specific for cyclin D1 showed strong positivity amongst neoplastic glial cells in the same glioma samples. No cyclin D1 mRNA or protein was detected in 5 normal brain specimens. Cyclin B, which has not been linked to tumorigenesis and serves as a marker for cellular proliferation, was expressed in all tumor, but not control, samples. These data provide the first evidence for the overexpression of cyclin D1 mRNA and protein in primary human gliomas, and are consistent with a proposed oncogenic role of cyclin D1 in these tumors. It is suggested that excessive levels of cyclin D1 with or without several other D-type cyclin proteins may lead to deregulation of G(1) control in subsets of human gliomas. These results are further discussed in the context of putative functional redundancy of D-type cyclins and the role of the D-type cyclin/p16-ink4/pRB pathway in tumorigenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Maxwell M, Galanopoulos T and Antoniades H: Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas. Int J Oncol 9: 493-497, 1996.
APA
Maxwell, M., Galanopoulos, T., & Antoniades, H. (1996). Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas. International Journal of Oncology, 9, 493-497. https://doi.org/10.3892/ijo.9.3.493
MLA
Maxwell, M., Galanopoulos, T., Antoniades, H."Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas". International Journal of Oncology 9.3 (1996): 493-497.
Chicago
Maxwell, M., Galanopoulos, T., Antoniades, H."Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas". International Journal of Oncology 9, no. 3 (1996): 493-497. https://doi.org/10.3892/ijo.9.3.493
Copy and paste a formatted citation
x
Spandidos Publications style
Maxwell M, Galanopoulos T and Antoniades H: Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas. Int J Oncol 9: 493-497, 1996.
APA
Maxwell, M., Galanopoulos, T., & Antoniades, H. (1996). Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas. International Journal of Oncology, 9, 493-497. https://doi.org/10.3892/ijo.9.3.493
MLA
Maxwell, M., Galanopoulos, T., Antoniades, H."Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas". International Journal of Oncology 9.3 (1996): 493-497.
Chicago
Maxwell, M., Galanopoulos, T., Antoniades, H."Cell-cycle regulator cyclin D1 mRNA and protein overexpression occurs in primary malignant gliomas". International Journal of Oncology 9, no. 3 (1996): 493-497. https://doi.org/10.3892/ijo.9.3.493
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