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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1996 Volume 9 Issue 3

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Article

Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305

  • Authors:
    • T Hiwasa
    • H Tokita
    • M Hirose
    • Y Ike
    • M Ohkoshi

  • View Affiliations / Copyright

    Affiliations: CHIBA CANC CTR,RES INST,DIV ANIM RES,CHUO KU,CHIBA 260,JAPAN. CHIBA CANC CTR,RES INST,CLIN LAB,CHUO KU,CHIBA 260,JAPAN. MITSUI PHARMACEUT INC,POSTMKT SURVEILLANCE DEPT,CHUO KU,TOKYO 103,JAPAN. UNIV TOKYO,FAC MED,DEPT ORAL SURG,BUNKYO KU,TOKYO 113,JAPAN.
  • Pages: 517-520
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.517
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Abstract

The effects of a synthetic serine protease inhibitor, FOY-305, on the proliferation of normal and transformed mouse fibroblasts were investigated in vitro by MTT colorimetric assay. FOY-305 inhibited the growth of normal NIH3T3 cells and their src- and erbB2-transformed cells with a half maximum inhibitory concentration (IC50) of 1-1.2 mg/ml whereas it suppressed the growth of ras-transformed cells more effectively (IC50 was 0.5-0.6 mg/ml). Flow cytometric analysis using synchronized NIH3T3 cells has shown that the growth-inhibitory activity of FOY-305 was due to the suppression of G(1)/S transition. The synergistic effects between FOY-305 and traditional anticancer drugs were also investigated by the MTT assay and the results showed that FOY-305 significantly enhanced the antiproliferative activities of 5-fluorouracil (5-FU), 1-hexylcarbamoyl-5-fluorouracil (HCFU), 7-ethyl-1-hydroxy-7-ethyl-10-[4-(1-piperidino)-1-piperidino] camptothecin (SN-38), pirarubicin (THP) and 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU).

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Copy and paste a formatted citation
Spandidos Publications style
Hiwasa T, Tokita H, Hirose M, Ike Y and Ohkoshi M: Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305. Int J Oncol 9: 517-520, 1996.
APA
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., & Ohkoshi, M. (1996). Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305. International Journal of Oncology, 9, 517-520. https://doi.org/10.3892/ijo.9.3.517
MLA
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., Ohkoshi, M."Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305". International Journal of Oncology 9.3 (1996): 517-520.
Chicago
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., Ohkoshi, M."Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305". International Journal of Oncology 9, no. 3 (1996): 517-520. https://doi.org/10.3892/ijo.9.3.517
Copy and paste a formatted citation
x
Spandidos Publications style
Hiwasa T, Tokita H, Hirose M, Ike Y and Ohkoshi M: Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305. Int J Oncol 9: 517-520, 1996.
APA
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., & Ohkoshi, M. (1996). Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305. International Journal of Oncology, 9, 517-520. https://doi.org/10.3892/ijo.9.3.517
MLA
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., Ohkoshi, M."Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305". International Journal of Oncology 9.3 (1996): 517-520.
Chicago
Hiwasa, T., Tokita, H., Hirose, M., Ike, Y., Ohkoshi, M."Enhancement of anti-proliferative activities of 5-FU, HCFU, SN-38, THP and ACNU by a serine protease inhibitor, FOY-305". International Journal of Oncology 9, no. 3 (1996): 517-520. https://doi.org/10.3892/ijo.9.3.517
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