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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1996 Volume 9 Issue 3

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Article

Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma

  • Authors:
    • M Colleoni
    • M Biasin
    • L Boni
    • P Nelli
    • F Pancheri
    • G Vicario
    • G Sgarbossa
    • G Mastrapasqua
    • D Infantolino
    • P Manente
  • View Affiliations / Copyright

    Affiliations: CITY HOSP,SERV ANATOMOPATHOL,I-31033 CASTELFRANCO VENE,ITALY. IST NAZL RIC CANC,SERV EPIDEMIOL,I-16132 GENOA,ITALY. CITY HOSP,DIV MED 1,I-31033 CASTELFRANCO VENE,ITALY.
  • Pages: 541-545
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.541
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Abstract

Recent studies indicate that evaluation of cell proliferation in mallignant tumors may have prognostic value, but limited data are available on its expression in hepatocellular carcinoma. We therefore evaluated the prognostic tool of PCNA antigen expression on paraffin-embedded sections of 54 patients with hepatocellular carcinoma and concomitant cirrhosis. According to the number of positive cells, the PCNA expression ranged between 0.8 and 47%, and was divided into two groups (Group A, PCNA less than or equal to 5.5%; Group B, PCNA >5.5%). The two groups of patients were numerically well balanced. Median survival was 16 months for group A and 12 months for group B. According to the Cox multivariate analysis, PCNA expression (P=0.002),TNM stage (P=0.009) and ECOG performance status (P<0.001) significantly correlated with survival. In conclusion, PCNA antigen expression was found to be a significant prognostic faeature in unresectable hepatocellular carcinoma and may be a useful tool for future trials.

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Copy and paste a formatted citation
Spandidos Publications style
Colleoni M, Biasin M, Boni L, Nelli P, Pancheri F, Vicario G, Sgarbossa G, Mastrapasqua G, Infantolino D, Manente P, Manente P, et al: Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma. Int J Oncol 9: 541-545, 1996.
APA
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G. ... Manente, P. (1996). Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma. International Journal of Oncology, 9, 541-545. https://doi.org/10.3892/ijo.9.3.541
MLA
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G., Sgarbossa, G., Mastrapasqua, G., Infantolino, D., Manente, P."Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma". International Journal of Oncology 9.3 (1996): 541-545.
Chicago
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G., Sgarbossa, G., Mastrapasqua, G., Infantolino, D., Manente, P."Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma". International Journal of Oncology 9, no. 3 (1996): 541-545. https://doi.org/10.3892/ijo.9.3.541
Copy and paste a formatted citation
x
Spandidos Publications style
Colleoni M, Biasin M, Boni L, Nelli P, Pancheri F, Vicario G, Sgarbossa G, Mastrapasqua G, Infantolino D, Manente P, Manente P, et al: Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma. Int J Oncol 9: 541-545, 1996.
APA
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G. ... Manente, P. (1996). Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma. International Journal of Oncology, 9, 541-545. https://doi.org/10.3892/ijo.9.3.541
MLA
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G., Sgarbossa, G., Mastrapasqua, G., Infantolino, D., Manente, P."Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma". International Journal of Oncology 9.3 (1996): 541-545.
Chicago
Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G., Sgarbossa, G., Mastrapasqua, G., Infantolino, D., Manente, P."Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma". International Journal of Oncology 9, no. 3 (1996): 541-545. https://doi.org/10.3892/ijo.9.3.541
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