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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 1996 Volume 9 Issue 3

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Article

Antibody-directed enzyme prodrug therapy (ADEPT)

  • Authors:
    • B Retta
    • P Burke
    • A Photiou
    • R Melton
    • E Eno-Amooquaye

  • View Affiliations / Copyright

    Affiliations: CHARING CROSS HOSP,DEPT MED ONCOL,CANC RES CAMPAIGN LABS,LONDON W6 8RF,ENGLAND. CHARING CROSS HOSP,DEPT MED ONCOL,CATHERINE GRIFFITHS CANC RES LAB,MELANOMA UNIT,LONDON W6 8RF,ENGLAND. PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,SALISBURY SP4 0JG,WILTS,ENGLAND.
  • Pages: 567-570
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.567
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Abstract

A conjugate of the bacterial enzyme carboxypeptidase G2 and the F(ab)(2) fragment of the anti-CEA monoclonal antibody A5B7 was directed in vitro at the human colon tumour cell line LS174T and the human non-small cell lung line COR-L23. Indirect immunofluorescence microscopy was used to show that the conjugate bound to LS174T cells but not to COR-L23. The cytotoxicity generated by addition of a phenol mustard prodrug to each cell line after pre-incubation with conjugate was found to be significantly greater for LS174T cells (IC50=0.24 mu M) than COR-L23 cells (IC50=108 mu M). However, for a 1:1 mixture of these cells an IC50, of 3.4 mu M was obtained. These data show that phenol mustard released by a localised conjugate can exert a bystander effect on neighbouring cells to which the conjugate does not bind.

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Copy and paste a formatted citation
Spandidos Publications style
Retta B, Burke P, Photiou A, Melton R and Eno-Amooquaye E: Antibody-directed enzyme prodrug therapy (ADEPT). Int J Oncol 9: 567-570, 1996.
APA
Retta, B., Burke, P., Photiou, A., Melton, R., & Eno-Amooquaye, E. (1996). Antibody-directed enzyme prodrug therapy (ADEPT). International Journal of Oncology, 9, 567-570. https://doi.org/10.3892/ijo.9.3.567
MLA
Retta, B., Burke, P., Photiou, A., Melton, R., Eno-Amooquaye, E."Antibody-directed enzyme prodrug therapy (ADEPT)". International Journal of Oncology 9.3 (1996): 567-570.
Chicago
Retta, B., Burke, P., Photiou, A., Melton, R., Eno-Amooquaye, E."Antibody-directed enzyme prodrug therapy (ADEPT)". International Journal of Oncology 9, no. 3 (1996): 567-570. https://doi.org/10.3892/ijo.9.3.567
Copy and paste a formatted citation
x
Spandidos Publications style
Retta B, Burke P, Photiou A, Melton R and Eno-Amooquaye E: Antibody-directed enzyme prodrug therapy (ADEPT). Int J Oncol 9: 567-570, 1996.
APA
Retta, B., Burke, P., Photiou, A., Melton, R., & Eno-Amooquaye, E. (1996). Antibody-directed enzyme prodrug therapy (ADEPT). International Journal of Oncology, 9, 567-570. https://doi.org/10.3892/ijo.9.3.567
MLA
Retta, B., Burke, P., Photiou, A., Melton, R., Eno-Amooquaye, E."Antibody-directed enzyme prodrug therapy (ADEPT)". International Journal of Oncology 9.3 (1996): 567-570.
Chicago
Retta, B., Burke, P., Photiou, A., Melton, R., Eno-Amooquaye, E."Antibody-directed enzyme prodrug therapy (ADEPT)". International Journal of Oncology 9, no. 3 (1996): 567-570. https://doi.org/10.3892/ijo.9.3.567
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