Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastases

  • Authors:
    • M Volm
    • R Koomagi
    • J Mattern
  • View Affiliations

  • Published online on: October 1, 1996     https://doi.org/10.3892/ijo.9.4.711
  • Pages: 711-714
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Abstract

Paraffin-embedded tumor sections from 166 patients with squamous cell lung carcinomas (n=114) and lung adenocarcinomas (n=52) were analyzed for the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) by immunohistochemistry. The results were compared with the incidence of metastatic spread. Sixty-five tumors were characterized as VEGF-negative and 101 tumors as VEGF-positive. Fifty-eight tumors were bFGF-negative and 108 tumors classified as bFGF-positive. Tumors with expression of VEGF or bFGF showed an increase in the formation of metastases. Combining the VEGF and bFGF expressions improved the prognostic value. Corresponding results were obtained when the analysis was restricted to squamous cell lung carcinomas or adenocarcinomas of the lung. These data provide evidence that VEGF and bFGF may be relevant factors associated with the metastatic potential of primary lung carcinomas.

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October 1996
Volume 9 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Volm M, Koomagi R and Mattern J: Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastases. Int J Oncol 9: 711-714, 1996.
APA
Volm, M., Koomagi, R., & Mattern, J. (1996). Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastases. International Journal of Oncology, 9, 711-714. https://doi.org/10.3892/ijo.9.4.711
MLA
Volm, M., Koomagi, R., Mattern, J."Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastases". International Journal of Oncology 9.4 (1996): 711-714.
Chicago
Volm, M., Koomagi, R., Mattern, J."Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastases". International Journal of Oncology 9, no. 4 (1996): 711-714. https://doi.org/10.3892/ijo.9.4.711